Genetic association of ANGPT2 with primary open-angle glaucoma

He, Jing Na; Ng, Tsz Kin; Lu, Shi Yao; Tam, Pancy Oi Sin; Chan, Poemen P.; Tham, Clement C.; Pang, Chi Pui; Chen, Li Jia; Chu, Wai Kit

doi:10.1186/s40662-022-00309-y

Eye and Vision

Table 3 Association of SNPs from ANGPT2 in females and males with NTG, HTG and POAG

From: Genetic association of ANGPT2 with primary open-angle glaucoma

SNP	Nucleotide change	Risk allele	RAF								HTG vs. Control				NTG vs. Control				POAG vs. Control
			HTG	HTG	NTG	NTG	POAG	POAG	Control	Control	P_male	Male OR (95% CI)	P_female	Female OR (95% CI)	P_male	OR_male (95% CI)	P_female	OR_female (95% CI)	P_male	OR_male (95% CI)	P_female	OR_female (95% CI)
			Male	Female	Male	Female	Male	Female	Male	Female
			(n = 295)	(n = 189)	(n = 278)	(n = 259)	(n = 573)	(n = 448)	(n = 184)	(n = 312)
Hong Kong
rs2515487	c.289-10440C>A	A	0.238	0.243	0.212	0.266	0.226	0.257	0.223	0.248	0.586	1.09 (0.80–1.49)	0.857	0.97 (0.72–1.31)	0.702	0.94 (0.68–1.29)	0.488	1.10 (0.84–1.43)	0.914	1.02 (0.77–1.35)	0.714	1.05 (0.83–1.32)
rs13255574	c.289-8669C>T	C	0.805	0.765	0.781	0.797	0.793	0.784	0.734	0.779	0.010*	1.50 (1.10–2.04)	0.605	0.92 (0.68–1.25)	0.101	1.29 (0.95–1.75)	0.448	1.12 (0.84–1.49)	0.017*	1.39 (1.06–1.83)	0.824	1.03 (0.80–1.32)
rs4455855	c.289-7422T>A	A	0.307	0.290	0.29	0.290	0.298	0.29	0.272	0.306	0.247	1.19 (0.89–1.58)	0.588	0.93 (0.70–1.23)	0.556	1.09 (0.81–1.47)	0.544	0.92 (0.72–1.19)	0.327	1.14 (0.88–1.48)	0.492	0.92 (0.74–1.16)
rs13269021	c.289-6755G>T	G	0.553	0.527	0.545	0.535	0.549	0.531	0.511	0.530	0.207	1.18 (0.91–1.54)	0.910	0.99 (0.76–1.27)	0.307	1.15 (0.88–1.49)	0.885	1.02 (0.81–1.29)	0.201	1.17 (0.92–1.47)	0.971	1.00 (0.82–1.23)
rs11775442	c.289-6350A>G	A	0.781	0.782	0.784	0.808	0.783	0.797	0.767	0.766	0.461	1.12 (0.82–1.53)	0.555	1.10 (0.81–1.49)	0.406	1.14 (0.83–1.56)	0.085	1.29 (0.97–1.71)	0.381	1.13 (0.86–1.49)	0.146	1.20 (0.94–1.54)
Shantou
rs2515487	c.289-10440C>A	A	0.295	0.263	0.295	0.264	0.296	0.262	0.298	0.272	0.909	0.99 (0.76–1.27)	0.808	0.96 (0.66–1.38)	0.936	0.98 (0.67–1.45)	0.864	0.96 (0.61–1.52)	0.937	0.99 (0.78–1.26)	0.746	0.95 (0.69–1.30)
rs2922869	c.289-9785T>C	T	0.712	0.770	0.721	0.736	0.713	0.757	0.713	0.695	0.980	1.00 (0.77–1.30)	0.037	1.49 (1.02–2.16)	0.849	1.04 (0.70–1.55)	0.383	1.23 (0.77–1.98)	0.999	1.00 (0.78–1.29)	0.051	1.37 (1.00–1.88)
rs13255574	c.289-8669C>T	C	0.771	0.821	0.799	0.759	0.775	0.798	0.765	0.760	0.809	1.04 (0.78–1.37)	0.082	1.44 (0.95–2.16)	0.394	1.22 (0.77–1.91)	0.98	0.99 (0.62–1.59)	0.668	1.06 (0.81–1.39)	0.226	1.23 (0.88–1.72)
rs4455855	c.289-7422T>A	A	0.339	0.282	0.346	0.255	0.341	0.271	0.340	0.319	0.960	0.99 (0.78–1.27)	0.300	0.83 (0.58–1.18)	0.889	1.03 (0.71–1.49)	0.193	0.74 (0.46–1.17)	0.981	1.00 (0.79–1.27)	0.128	0.78 (0.57–1.07)
rs13269021	c.289-6755G>T	G	0.577	0.602	0.658	0.580	0.596	0.591	0.539	0.443	0.197	1.17 (0.92–1.49)	0.733	1.06 (0.77–1.46)	0.008*	1.67 (1.14–2.43)	0.874	0.97 (0.63–1.48)	0.040	1.27 (1.01–1.60)	0.934	1.01 (0.76–1.34)
rs11775442	c.289-6350A>G	A	0.798	0.833	0.796	0.778	0.796	0.813	0.793	0.798	0.870	1.02 (0.77–1.36)	0.272	1.26 (0.84–1.89)	0.946	1.02 (0.66–1.57)	0.652	0.90 (0.55–1.45)	0.900	1.02 (0.78–1.33)	0.597	1.10 (0.78–1.54)

CI = confidence interval; HTG = high tension glaucoma; NTG = normal tension glaucoma; OR = odds ratio; POAG = primary open-angle glaucoma; RAF = risk allele frequency
^*P value < 0.05

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