Refractive lens exchange in modern practice: when and when not to do it?
© Alió et al.; licensee BioMed Central Ltd. 2014
Received: 4 June 2014
Accepted: 5 November 2014
Published: 10 December 2014
Cataract surgery due to advances in small incision surgery evolved from a procedure concerned with the primary focus on the safe removal of cataractous lens to a procedure focused on the best possible postoperative refractive result. As the outcomes of cataract surgery became better, the use of lens surgery as a refractive modality in patients without cataracts has increased in interest and in popularity. Removal of the crystalline lens for refractive purposes or refractive lens exchange (RLE) presents several advantages over corneal refractive surgery. Patients with high degrees of myopia, hyperopia and astigmatism are still not good candidates for laser surgery. Moreover, presbyopia can currently only be corrected with monovision or reading spectacles.
RLE supplemented with multifocal or accommodating intraocular lenses (IOLs) in combination with corneal astigmatic procedures might address all refractive errors including presbyopia, and eliminate the future need for cataract surgery.
Historical background of the clear lens extraction
The concept of clear lens extraction dates back to the XVIIIth century, when Abbé Desmonceaux in 1776 was the first to perform such a surgery in France. First systematically conducted operations of clear lens exchange in high myopia in children and young adults were made by Polish ophthalmologist Vincenz Fukala in the last decades of the 19th century in Vienna. Fukala’s operation in myopic patients was widespread among many ophthalmologists in Europe, but due to high rates of post-surgical retinal detachment, the procedure was gradually abandoned at the beginning of the 20th century -.
An intensive development of new concepts and techniques in lens surgery in the 20th century led to clear lens extraction again. The introduction of first posterior–chamber intraocular lens (PC-IOL) by Harold Ridley in 1949 was the first big step in contemporary cataract surgery. In 1952, Baron implanted the first anterior chamber IOL fixated in iridocorneal angle. Then, the concept of lens emulsification with ultrasounds as also the irrigation/aspiration (I/A) technique in phacoemulsification of cataract surgery were developed. Complete and much easier lens removal significantly decreased the number of post-surgical complications. Another huge step in lens surgery was the invention of a foldable intraocular lens (IOL) in the 1980s. This was the beginning of micro-incision cataract surgery (MICS).
Surgical techniques for refractive lens exchange
The surgical technique of refractive lens exchange (RLE) is a variation of standard cataract surgery. The main elements that make a difference between standard cataract surgery and RLE are: clarity of crystalline lens in the absence of cataract, and a presence of abnormal ocular anatomy resulting in a high refractive error, which becomes an indication for RLE. Correction of presbyopia and gaining spectacle-independence in elderly patients with no anatomical ocular pathologies and normal axial length is also an important indication for RLE.
Anatomically minimally invasive surgery with minimal trauma to the corneal endothelium, iris, and other ocular tissues.
A secure, watertight 2.2 mm (or less) micro incision in clear cornea, optimally 1.0 mm from the limbus, situated at the steepest corneal meridian in order to minimize surgically induced astigmatism or to reduce pre-existing corneal astigmatism.
Fixation of an appropriate PC-IOL in the capsular bag with low induction of posterior capsular opacification (PCO).
In eyes with high axial myopia, depth and stability of the anterior chamber are abnormal, which necessitates the use of dispersive (heavy) viscoelastic material.
In eyes with excessive axial length, the risk of perforation during retrobulbar injections  is high.
In short, hyperopic eyes, an increased risk of choroidal effusion and macular edema should be considered.
MICS is an approach to RLE surgery through an incision less than 1.8 mm with the purpose of reducing surgical invasiveness and improving surgical outcomes. MICS favors the use of fluidics, reducing the use of phacoemulsification power. Bimanuality provides an opportunity for easy and comfortable manipulation in the anterior chamber area versus standard coaxial technique. Long term stability of MICS outcomes and having a wide range of surgical capacities make MICS the most modern and adequate approach to minimally invasive RLE surgery.
Intraocular lens and IOL power selection in refractive lens exchange
The intraocular power calculations for clear lensectomy are not different from standard calculations used for cataract extraction. The patients are usually much younger, however, and the loss of accommodation should be discussed thoroughly . The actual desired postoperative refraction should also be discussed since a small degree of myopia (–0.50 D) may be desirable in the case of monofocal IOL use. Apart from appropriate patient selection, the most important assessment for successful multifocal lens use requires precise preoperative measurements of axial length and accurate lens power calculations. Optical and immersion ultrasound biometry techniques in combination with the Holladay 2 formula can yield accurate and consistent results. When determining lens power calculations, the Holladay 2 formula takes into account disparities in anterior segment and axial lengths by adding the white-to-white corneal diameter and lens thickness into the formula .
Axial length<22.0 mm
Axial length 22.0 mm
Axial length 24.5 mm
Axial length >26.0 mm
1 st choice formula
2 nd choice formula
The study by Wang and Chang  compared different methods of calculating IOL power in eyes with different axial lengths. They found that employing the Haigis formula resulted in the smallest post-operative median absolute error (MedAE) and mean absolute error (MAE). The Haigis formula requires three variables: K - corneal power (measured in radii of curvatures instead of dioptric values), AL – axial length of the eye, and ACD - (phakic) anterior chamber depth.
In a normal cornea, standard keratometry and computed corneal topography are accurate in measuring four sample points to determine the steepest and flattest meridians of the cornea, thus yielding accurate values for the central corneal power. In an irregular cornea, such as one that had undergone prior keratorefractive surgery, these four simple points are insufficient in providing an accurate estimate of the center corneal refractive power .
Many different lens equations and strategies exist for post-refractive eyes. Some equations use historical data (pre-operative refraction readings and keratometry) while others do not. Some strategies involve using specialized equipment, like intraoperative aberrometry, Scheimpflug tomography or anterior segment optical coherence topography (OCT), to measure additional corneal parameters that could be helpful in achieving a more accurate lens power calculation.
Inaccurate measurement of anterior corneal curvature by standard keratometry or computerized videokeratography (CVK): Standard keratometry or simulated keratometry from CVK measures only four paracentral points or small regions. This is insufficient for the post-surgical cornea, which can have wide ranges of curvature even within the central 3.0 mm region.
Inaccurate calculation of corneal refractive power from the anterior corneal curvature by using the standardized value for refractive index of the cornea (1.3375 in most keratometers and CVK devices): based on the assumption that there is a stable anterior corneal curvature/posterior corneal curvature ratio, the standardized index of refraction was used to convert the measurements of anterior radius of curvature for the estimation of total corneal refractive power. However, procedures that remove corneal tissue [e.g., photorefractive keratectomy (PRK) or laser in situ keratomileusis (LASIK)] change the relationship between the front and back surfaces of the cornea, thus invalidating the use of the standardized refraction index .
The choice of using the IOL power calculation method is an important issue in RLE. In long, myopic eyes especially, the problems related to standard IOL power calculation methods are well known.
Refractive lens exchange in myopia
Refractive lens extraction in myopia
No. of eyes/patients
Mean preoperative SE(D)/axial length(mm)
Postoperative refractive error
Retinal detachment rate
Arne, 2004 CLE versus pIOL 
36/18 RLE 41/21 pIOL
SE: -16.7 RLE -13.6 pIOL
At 1 year: pIOL -78% better than preop
RLE - 83.3% better than preop
-1.88 ± 0.83 D RLE
-1.06 ± 0.78 D pIOL
2/77 eyes (2.59%) only in CLE group
Emarah, El-Helw, 2010 
28/16 RLE 27/15 ICL
SE: -17.54 RLE -16.45 ICL
CDVA 0.39- RLE group
CDVA 0.51- ICL group
RLE group: CDVA 0.61,
71.4% postop UCVA better thanpreop CDVA
ICL group: CDVA 0.79,
51.8% postop UDVA better than preop CDVA
SE: -0.99 ± 0.88 D-RLE
-0.63 ± 0.86 D-ICL
RLE: 82% in goal refraction
ICL: 77% in goal refraction both groups 100% within ±2.00 D of goal refraction
Gabric, Dekaris et al., 2002 
CDVA 0.5 in 72% of eyes
4 years after surgery: UDVA ≥0.5 in 58.3% BCVA ≥0.5 in 83.3%
70.8% - emmetropia 86.5% within ± 1.0 D of goal refraction 95.8% within ± 2.0 D of goal refraction
1 eye (0.72%)
Horgan et al., 2005 
CDVA ≥0.5 in 52% eyes
Mean UCVA 0.3
-1.09 ± 1.34 D
2/62 eyes (3.2%)
Ravalico et al., 2003 
388/273, RLE/cataract extraction
SE -2.00 ± 1.62 D
1 eye (0.26%)
Fernandez- Vega et al., 2003 
83.7% - better than preop
12.6% - equal to preop 3.7% - worse than preop
Mean -1.22 D 41% -within ± 1.00 D of emmetropia 79% - within ± 2.00 D of emmetropia
Guell et al., 2003 
44/30, RLE or initial lens opacification
CDVA ≥0.5 in 63.2% of patients
CDVA ≥0.5 in 82.9%
Mean -1.05 D
52.7% within ± 1.00 D of emmetropia 94.1% within ± 2.00 D of emmetropia
In a retrospective study , phakic IOL implantation and RLE were compared in a group of highly myopic 30-50 year-old patients. RLE was performed in eyes with the anterior chamber shallower than 2.8 mm or at the beginning of presbyopia, whereas phakic IOL was implanted in eyes with no recent visual acuity decrease or presbyopic refraction changes. At one-year follow-up, the results were similar in both groups. In conclusion, phakic lens implantation in myopic patients of 30-50 year-olds was a more adequate refractive technique with lower risk of corrected distance visual acuity (CDVA) loss, and extraction of crystalline lens can be performed as a secondary procedure.
Another study  compared RLE and collamer lens (Visian) implantation in patients less than 45 years old with myopia greater than -12.0 D. The RLE group showed better results for postoperative CDVA, and had no serious complications such as retinal detachment (RD), endophthalmitis of inflammatory reaction. In the implantable collamer lens (ICL) group however, lens opacity, pigment dispersion, macular hemorrhage or pupillary block glaucoma occurred. Four eyes from the RLE group required yttrium aluminum garnet (YAG) capsulotomy for PCO.
The issue of different techniques used in RLE in high myopia was also studied. It was shown that considering effective phacoaspiration time, complication rates and intra- and post-operative complications of supracapsular phacoaspiration were safer and presented lower risk of complications than endocapsular phacoaspiration using the divide and conquer technique . The preoperative and postoperative CDVA did not differ significantly between the 2 groups.
Retinal detachment after RLE in highly myopic eyes
Retinal detachment rate (%)
Type of study,No. of eyes
Type of surgery
Fernandez-Vega et al. (2003) 
RLE, high myopia
Pucci et al. (2001) 
RLE, high myopia
Neuhann et al. (2007) 
RLE, high myopia
Lyle and Jin, (1994) 
RLE, high myopia
Barraquer et al. (1994) 
RLE, high myopia
Gris et al. (1996) 
RLE, high myopia
Lee et al. (1996) 
RLE, high myopia
Jimenez – Alfaro et al. (1998) 
RLE, high myopia
Colin et al. (1999) 
RLE, high myopia
Alio et al. (2007) 
RLE, high myopia
It was argued  that in eyes with myopia greater than -8.0 D in pre-presbyopic patients who still accommodate, RLE should not be considered due to increased risk of RD (2.8-8.1%) and phakic lens implantation should be performed in such cases. It was shown in a long-term follow-up study of RLE in high myopia , that myopic macular degeneration developed post-surgically in 12 eyes, YAG-capsulotomy for PCO was required in 38/62 eyes, and retinal rhegmatogenous RD in 2/62 eyes.
In the analysis of post-operative RD, two factors are considered important: intraoperative capsular tear with vitreous loss and neodymium-doped yttrium aluminum garnet (Nd:YAG) laser capsulotomy performed for PCO.
Preoperative determination of RD risk, especially in myopic eyes with axial length greater than 26.0 mm and spherical equivalent superior to -6.00 D is of great importance . In young myopic patients, clear lens extraction can induce vitreous changes and increase tractions of the retina, which do not occur in old age after cataract extraction. In a study by Alio et al.  The patients were divided into 2 groups according to age (group 1 ≤ 50 years and group 2 > 50 years) and axial length (≤28.0 mm and >28.0 mm). Eyes with longer axial lengths demonstrated higher incidences of RD. This complication was also more frequent in younger patients (3.65% in group 1 comparing to 2.52% in group 2, p < 0.05). The risk factors of post-RLE RD include : increased axial length, age less than 50 years, male sex, Caucasian race, peripheral retinal degenerations, intraoperative rupture of the posterior capsule, and Nd:YAG capsulotomy for PCO.
A combined operation of pars plana vitrectomy with clear lens extraction in correction of high myopia in patients can also be considered to reduce the risk of RD .
Among frequent post-operative complications, RLE may be followed by cystoid macular edema in the first few weeks after surgery. The greatest risk of this complication is carried when the procedure is done for correction of high myopia. RLE in highly myopic eyes is recommended after detachment of vitreous body, which diminishes the risk of RD.
A long-term complication of RLE procedure is PCO. It can develop months to years after the surgical procedure. YAG capsulotomy can be more risky in myopic eyes. Each millimeter of increased axial length increases the risk of RD after YAG capsulotomy by a factor of 1.5 . No preoperative prophylaxis can be made however, there are a number of intraoperative methods that can be used to reduce the incidence of PCO including the capsulorrhexis overling the edge of the IOL optic, cortical cleaving hydrodissection, meticulous cortical clean-up and the implantation of a sharp posterior edge IOL. As much as possible, YAG capsulotomy should be avoided . Another complication of RLE might be a worsened twilight vision with halo perception and glare after the implantation of multifocal IOL .
The less common complications include choroidal neovascularization (CNV) formation . CNV formation after clear lens extraction was reported in all patients with preoperative macular lacquer cracks , but the presence of myopic CNV in the fellow eye was also a risk factor for the operated eye . There is no clear explanation as to why eyes undergoing RLE are more susceptible to early age-related macular degeneration (AMD) occurrence with or without CNV formation , but inflammatory mediators associated with biochemical environmental changes within the eye such as increased free radicals or growth factors can play important roles.
Eyes with advanced peripheral lattice degenerations
Young eyes with no posterior vitreous detachment
Laquer cracs in high myopia or myopic CNV in the fellow eye
Presbyopic eyes with macular degeneration beginning in the fellow eye
Refractive lens exchange in hyperopia
Small, hyperopic eyes with shallow anterior chambers are more predisposed to closed-angle glaucoma. This makes even moderate hyperopia an indication for RLE, offering very good benefit/risk ratio . In elderly patients where accommodation is weakened despite the clear crystalline lens, its removal with multifocal IOL implantation can be a good option in the absence of other ocular pathologies.
Refractive lens exchange in hyperopia (visual acuities in decimal values)
No. of eyes/patients/mean age(years)
+9.19 ± 0.34 (distance)
+10.41 ± 0.32 (near)
At 1 year:
+0.02 ± 0.80 (distance)
+1.87 ± 0.31 (near)
Count fingers – 31 eyes, 0.1 VA obtained in 4 eyes
0.94 ± 0.014
1.037 ± 0.22
0.8 (0.5 to 1.0)
91.4% within ±1.00 D of target refraction
Fink et al.,
Group A: (preop SE ≤ +4 D), 61.9
Group B: (preop SE > +4 D) 54.7
Group A: SE: +2.26 ± 0.94
Group B: SE: +6.32 ± 1.32
-0.18 ± 0.73
-0.19 ± 1.28
Group A: 0.19
Group B: 0.05
Group A: 1.13
Group B: 1.04
Group A:0.81 ± 0.30
Group B:0.58 ± 0.33
Group A: 1.10 ± 0.17
Group B: 1.02 ± 0.16
Alfonso, et al., 2009
RLE after previous hyperopic LASIK 
Pre-IOL SE: Mean +1.32
Mean postop SE: -0.064 ± 0.513
0.189 ± 0.175 logMAR
0.049 ± 0.071 logMAR
Mean efficacy index:
Mean safety index:
0.113 ± 0.101 logMAR
CDVA: 0.046 ± 0.063 logMAR
All eyes within ±1.25 D of target refraction, 73.17% - within ±0.50 D
Preetha Goel, Patel et al.,
(6 to 35 months)
+6.66 ± 2.17
(+4.75 to +13.0)
(0 to +2.50)
0.10 ± 0.09
(0.03 to 0.25)
0.53 ± 0.29
(0.10 to 1.00)
0.45 ± 0.25
(0.10 to 1.00)
0.63 ± 0.30
(0.10 to 1.00)
Pop, Payette 2004 
Artisan phakic lens versus RLE + IOL
- RLE + IOL
+2.75 to +9.25
RLE + IOL:
+2.75 to +7.50
2 months postop:
Artisan: 78% within ±1.00 D of emmetropia
RLE + IOL: 91% within ±1.00 D of emmetropia
≥0.8: 0 in both groups
≥0.5: 0 in both groups
Preoperative UDVA of both groups is not reported in details.
RLE + IOL:
2 months postop:
64% RLE + IOL
82% RLE + IOL
Koladhouz – Isfahani et al., 1999 
39% within ±1.00 D of target refraction
A study by Preetha et al.  evaluated the safety, efficacy and predictability of clear lens extraction with PC-IOL implantation in 20 eyes of 12 hyperopic patients. The efficacy index [mean postoperative uncorrected distance visual acuity (UDVA)/mean preoperative corrected distance visual acuity (CDVA)] was 0.84 and the safety index (mean postoperative CDVA/mean preoperative CDVA) was 1.1. No intraoperative complications occurred, although the main postoperative complication was PCO.
Hoffman et al.  reported the successful results of bilateral RLE with the use of multifocal AMO Array lens in 50 hyperopic and presbyopic patients. Ninety-two percent of patients gained 20/40 and Jaeger 4 print, and all patients were able to read 20/40 and Jaeger 5 print.
Another study  compared RLE with pseudophakic IOL implant and phakic Artisan iris-claw IOL in the treatment of hyperopia. At 1 month postoperatively, the uncorrected visual acuity (UCVA) of the RLE group was slightly better than the Artisan group in that the results were inversed at 2 months postoperatively. Mean endothelial cell loss at 1 year after surgery was 8-10% after phacoemulsification, whereas in the Artisan group 6 months after phakic implantation it was 2.3%. No RD was observed in both groups.
RLE with spherical diffractive IOL implantation in eyes after hyperopic LASIK also revealed to be safe, effective and predictable .
Comparing the magnitude of wavefront aberrations in eyes after hyperopic LASIK and RLE , the results presented as follows: in the LASIK group, postoperative refraction change significantly correlated with total, corneal and internal RMS-HOA (root-mean-square higher-order aberrations) and spherical aberrations. For the RLE group, no such correlations were noted. RLE was revealed then to be much safer and a better refractive procedure for minimizing total higher order optical aberrations which occur after hyperopic refractive surgery.
RLE can be used to treat hyperopia in extremely short, nanophthalmic eyes or eyes of patients who underwent laser refractive surgery and require correction of remaining hyperopia. In these cases, an accurate axial length measurement to achieve emmetropia is essential ,.
Good refraction results were described  in highly hyperopic eyes (+7.5 D both eyes) after RLE with IOL implantation in patients with congenital systemic syndromes associated with severe developmental delay who do not cooperate and cannot wear spectacles.
Apart from well-known cataract surgery complications, the risk of complications in short, hyperopic eyes (axial length <21.0 mm) is mostly due to anatomical conditions – less space in the anterior segment and shallow anterior chamber predispose to pupillary block or secondary postoperative intraocular pressure (IOP) increase. The postoperative uveal effusion is also seen more often in hyperopic eyes .
Beginning presbyopia with weakened accommodation of crystalline lens
High order aberrations, when laser surgery need to be avoided
High hyperopia in patients with congenital systemic condition who are unable to wear spectacles or contact lenses
Refractive lens exchange in children
So far only a few studies have been made on this subject, and refractive surgery with the use of excimer laser was more commonly investigated. However, excimer laser correction of refractive errors is limited to those between +6.0 and -12.0 D . Refractive errors beyond this range require other methods of correction.
In children, main indications for refractive surgery are severe anisometropia and severe bilateral ametropia .
According to Tychsen et al.  one of the major recommendations for pediatric RLE in non-compliant children is a shallow anterior chamber (<3.2 mm where phakic IOL is impossible or too risky to be implanted). The most frequent complication of such surgery is late aphakic/pseudophakic RD, estimated for about 3%. Barrier diode laser may be applied in eyes whose axial length exceeds 29.0 mm, in order to avoid or reduce RD.
Refractive lens extraction in children
No. of eyes/patients
Mean preoperative SE(D)
Mean preoperative VA
Mean postoperative VA
Mean follow-up time
Tychsen et al., 2006 
0 to +3.0
Ali et al., 2007 
0 to +4.0
Bhattacharjee et al., 2010 
2/1 bilateral microsphrophakia, angle closure glaucoma
-23.0 sph -1.0 cyl ax 80
-24.0 sph -1.0 cyl ax 100
0.33 RE, CDVA, 0.25 LE, CDVA
1.0 both eyes
None, After 1 year UDVA 1.0 in both eyes
Depending on preoperative refractive error, some congenital lens abnormalities (microspherophakia, high myopia/hyperopia, secondary glaucoma) with corresponding refractive error can be an indication for RLE with or without IOL implantation .
RLE can serve also in less common situations for e.g. as a method of correcting persistent accommodating spasms after head trauma .
High anisometropia or severe bilateral ametropia
Congenital conditions disabling proper binocular vision
Non-compliant children with high refractive errors where treatment with refractive laser surgery is impossible
Refractive lens exchange in astigmatism
Previously, in cases of residual astigmatism after cataract surgery or RLE, the only solution was additional corneal laser surgery – LASIK, PRK or soft contact lenses if the correction was still inadequate . Pop et al.  studied PRK and LASIK after RLE with spherical IOL implantation for hyperopia or astigmatism. A laser procedure was performed to correct residual ametropia after the first surgery. Both methods of laser correction showed to be equally effective. RLE with IOL implantation was more risky in terms of sight-threatening complications than refractive surgery alone. In selected cases of hyperopic eyes after RLE with residual ametropia however, laser adjustment can be appropriate.
The invention of toric IOLs by Shimizu in 1992 became a milestone in the treatment of astigmatism. Posterior chamber toric lens implantation is a new, highly predictable surgical option for patients with pre-existing corneal astigmatism. A study by Sun et al.  evaluated the results of toric IOL implantation for cataract extraction and RLE in 130 eyes of patients with pre-existing astigmatism. In the control group of 51 eyes with pre-existing astigmatism of similar degrees, an implantation of spherical IOL combined with limbal relaxing incisions was performed. In both groups, a significant decrease of refractive astigmatism was achieved. There was no significant superiority of one method over another. The number of eyes with residual astigmatism of 0.75 D or less was larger in the toric IOL group.
Another prospective study  performed a RLE in astigmatic eyes with implantation of an AcrySof Toric IOL to correct the preoperative regular corneal astigmatism, varying from 1.0 to 4.0 D. After surgery, the mean reduction of astigmatism was 80%. Good rotational stability was achieved – no eye needed a repositioning of IOL. No eye had any kind of complications, neither intraoperative nor postoperative.
Refractive lens extraction in astigmatism with implantation of toric IOLs (visual acuities is decimal values/ decimal scale)
No. of eyes/patients/mean age(years)
Keratometry(K1,K2)(D)/Axial length(mm)/Mean IOL power(D)
Preop SE/mean defocus equivalent/mean refractive cylinder(D)
Postop SE/mean defocus equivalent/mean refractive cylinder(D)
Sun et al., 2000 (retrospective) 
122 eyes – cataract surgery
8 eyes – RLE
K2-K1 = 2.59 ± 0.82 (total)
Mean refractive cylinder preop:
Toric group: 2.57 ± 1.15
Non–toric group: 2.58 ± 0.89
Mean SE: -0.51 ± 0.65 refractive cylinder:
-1.03 ± 0.79
Mean SE: -0.52 ± 0.78
-1.49 ± 0.75
The authors only mention preop UCVA:
Toric group: 0.74 ± 0.25 logMAR
0.78 ± 0.30 logMAR
Preop BCVA – N/R
84% of eyes ≥0.5
Non-toric group: 76% of eyes ≥0.5
The authors only mention postop UCVA:
Toric group: 69% ≥0.66
Non-toric group: 70.3% ≥0.66
Postop BCVA- N/R
Jaimes et al., 2011 (retrospective) 
1- pellucid marginal degeneration
Mean K readings: 46.31 ± 3.39
AL – N/R
IOL: AcrySof ToricSN60T3-T9
mean power =14.9
Sphere: -5.25 ± 6.40 Cylinder: +3.95 ± 1.30
SE refraction: -7.10 ± 6.41
Sphere: +0.22 ± 1.01
Cylinder: +1.36 ± 1.17
SE refraction: -0.46 ± 1.12
CDVA: 0.28 ± 0.55 logMAR
0.29 ± 0.23 logMAR
CDVA: 0.11 ± 0.12 logMAR
Leccisotti, 2006 
-11.0 ± 4.65 /12.0 ± 4.64/1.86 ± 1.39
-1.31 ± 1.08 /1.94 ± 1.57/1.22 ± 1.37
0.55 ± 0.23
0.48 ± 0.25
0.76 ± 0.23 at 12 months
Ruiz-Mesa et al., 2009 (prospective) 
K1 = 43.47 ± 1.20
K2 = 45.75 ± 1.41
AL =23.54 ± 2.04
IOL power =20.87 ± 5.99
Mean refractive sphere: -0.70 ± 5.32
Mean refractive cylinder: -2.46 ± 0.99
Mean refractive sphere: -0.007 ± 0.61
Mean refractive cylinder: -0.53 ± 0.30
0.87 ± 0.10
0.89 ± 0.09, 56.3% of eyes ≥1.00
84.3% of eyes ≥0.80
0.95 ± 0.09
Pop et al., 2001 (retrospective) 
RLE for hyperopia
31 eyes – retreated with PRK
34 eyes- retreated with LASIK
Mean K readings: 43.23 ± 1.92
Mean AL: 21.33
Mean IOL power: 32.7 ± 6.0
3.1% of eyes within ±0.5 D of emmetropia
4.6% of eyes within ±1.0 D of emmetropia
96% of eyes within ±2.0 D of emmetropia
79% of eyes within ±1.0 D of emmetropia
51% of eyes within ±0.5 D of emmetropia
18.5% of eyes ≥1.0 before RLE
60.9% of eyes ≥1.0 before laser adjustment
85% of eyes ≥0.5
46% of eyes ≥1.0
CDVA at 12 months:
100% ≥0.5 after PRK
95.7% ≥0.5 after LASIK
The issue of RLE for correcting a myopic spherical error or RLE with toric lens implantation associated with stable keratoconus in stage I and II was also undertaken ,. Keratoconus laser refractive surgery or phakic IOL implantation has only a limited value and is also associated with a reduction in corneal endothelial cell density.
The important potential complication of RLE for the correction of astigmatism to be avoided is a mistake in IOL power calculation, which results in a postoperative refraction that is different from the target refraction . As patients’ expectations in this type of surgery are higher than those after cataract extraction, the surgeon must be extremely thorough while choosing the calculation formula and the type of IOL to be implanted.
When considering RLE in astigmatic eyes, the surgeon must be conscious of unpredictability of the results and more often than not, only a slight improvement of the patient’s vision. It is not the preferable method of correction of cylindric errors. All the other possibilities must be introduced to the patient preoperatively.
Refractive lens exchange in presbyopia
In recent years, several presbyopia-correcting IOLs using accommodating or multifocal designs have been developed. The aim is to restore distance, near, and intermediate visual functions after cataract surgery ,.
Multifocal IOL optical designs attempt to provide patients with spectacle independence for distance and near visual conditions by generating several foci at different distances ,. The ability of multifocal IOLs to improve the near visual function in pseudophakic patients has been confirmed by several studies ,-. This provides near vision at the expense of reducing contrast sensitivity and causing photic visual phenomena, such as increased glare and halos ,-. Special considerations should be made when a surgeon plans to implant a multifocal IOL in patients with high ametropia as magnification and minimization of the retinal image in myopic and hyperopic patients respectively, may play a significant role in the visual outcome .
Accommodating IOLs were designed to mimic the physiologic mechanism of accommodation to avoid the optical side effects of multifocal IOLs. Several mechanisms have been described for this kind of IOL ,. One is the axial (backward and forward) movement of the IOL optic where the ciliary muscle contracts and relaxes. The efficiency of the single-optic principle is dependent on the optical power of the displaced IOL, providing limited near vision . To circumvent this, a dual-optic IOL was designed with a high plus power moving optic coupled with a low-power static minus lens; the two are joined by a spring haptic  (Crystalens HD IOL, Bausch & Lomb). The biconvex single-optic accommodating IOL is of a biocompatible third-generation silicone (Biosil) with a refractive index of 1.428. It has a central bispheric modification that was designed to increase depth of focus for better intermediate focus and near focus [Synchrony (Visiogen, Inc.)]. The single-piece silicone IOL has 2 main components (anterior and posterior). Each component has the general design of a plate-haptic silicone IOL; a bridge with a spring function connects the 2 components. The anterior IOL component has a high plus power beyond that required to produce emmetropia. The posterior IOL component has a minus power to return the eye to emmetropia. Once the IOL is in the capsular bag, the tension of the bag compresses the optics. This leads to strain energy in the haptics that is released when there is an attempt to accommodate.
In a comparative study between multifocal and accommodating IOLs , it was found that both IOLs can successfully restore the distance visual function after cataract surgery and provide an improvement in near vision. Of note, the low add power of the multifocal refractive IOL provides a wide range of focus, especially in intermediate vision, and provides better near-vision outcomes. Both IOL models had limitations in providing complete near-vision outcomes. The low add multifocal IOL could possibly be a better option for patients with significant intermediate-vision demands.
Modern indications for refractive lens exchange with a balanced risk/benefit ratio
Our current ability to achieve emmetropia following refractive lens surgery rivals the results of corneal refractive surgery, yet it covers a much wider range of refractive errors. While phakic refractive lenses extend the range of correction for younger patients, RLE also offers, with new IOLs, a high probability of achieving functional binocular vision at distance, intermediate and near focal lengths. For these reasons, RLE will become the dominant refractive procedure for patients past the age of presbyopia. With RLE, patients can enjoy a predictable refractive procedure with rapid recovery, which addresses all types of refractive errors, including presbyopia, and as a bonus they will never develop cataracts .
Desire for a life free of spectacle and contact lens correction is not limited to low and moderate myopes under the age of 40. The high myope with an accommodative reserve may be a good candidate for phakic refractive lens implantation, and the presbyopic hyperope has become well recognized as a candidate for RLE with an accommodating or multifocal IOL . A myope over the age of 45, however, may be greeted with skepticism. Surgeons worry that presbyopic low myopes may be unsatisfied with a simple trade off – distance correction for near after bilateral LASIK or a compromise of depth perception with monovision – since multifocal or accommodating IOL may not offer the same quality of near vision they already have without correction. RLE for moderate to high myopes may raise concerns about significant complications, especially RD. In particular, eyes with long axial length and vitreoretinal changes consistent with axial myopia may be at higher risk for RD following lens extraction and IOL implantation.
A study that analyzed trends in refractive surgery in Germany over a 3-year period , showed that the predominant type of laser refractive surgery was LASIK, but RLE remained one of the most common non-corneal procedures, and in fact is more popular than phakic IOLs. The refractive surgery style in Germany is comparable to trends in other European countries. Moreover, it was argued that RLE provides greater depth of focus than phakic lenses through the use of multifocal and accommodative lenses. A comparative study of phakic IOLs and RLE  underlined that selection between these two procedures depends on various factors, such as a patient’s age, expectations, lifestyle and personality. It was suggested that in younger (<55 years of age) and myopic patients, RD following the procedure must be of concern and it is the best to perform RLE in patients with complete posterior vitreous detachment. Moreover, in hyperopic patients, RLE is a procedure of choice mostly because of anatomic dimensions of their eyes.
Since these are entirely elective procedures, minimizing risk is critical to the success of RLE and refractive surgery in general. Several conclusions emerge from the literature on RD following RLE ,.
First, careful preoperative examination and counselling should precede any decision to operate. Complete funduscopic examination with scleral depression and determination of the state of the vitreous body comprise essential steps in the examination. Referral to a vitreoretinal specialist should be entertained if any doubt emerges concerning the nature of a lesion or the indication for prophylaxis.
Second, surgical principles should emphasize minimal disturbance of the intraocular environment. Microincisional techniques facilitate the maintenance of a stable chamber, construction of a round and centered capsulorrhexis [continuous curvilinear capsulorrhexis (CCC)], effective cortical cleaving hydrodissection, efficient aspiration of lens material without application of ultrasound energy, and safe bimanual cortical clean-up through two paracentesis-type incisions. A fresh temporal clear corneal incision may be constructed for introduction of the IOL. All incisions should be Seidel negative at the conclusion of the case ,,.
Third, eventual YAG capsulotomy should be avoided if possible. The construction of a capsulorrhexis that completely overlies the edge of the IOL optic, together with the use of cortical cleaving hydrodissection, meticulous cortical clean-up, and the implantation of an IOL with a sharp posterior edge, all facilitate maintenance of a clear posterior capsule. By following these guidelines, we may be able to obtain the highest benefits with the least possible risks ,.
In conclusion, RLE is an elective intraocular surgery that needs to be minimally invasive, and performed with precision and high accuracy. The indication of this surgery is the presence of high refractive error in the absence of cataract and requires an approach with the risk–benefit ratio in mind depending on the age, refractive condition and pre-operative condition. In general, RLE should be performed only in presbyopic eyes. The main challenge involved is to reach emmetropia. With the rapid recovery and astigmatically neutral incisions currently used for modern cataract surgery, this procedure can be done with greater predictability . For restoration of near, intermediate and far vision, multifocal IOLs are currently superior to available accommodating IOLs . Successful integration of RLE into the general ophthalmologist’s practice is fairly straightforward if the surgeon is following the modern methods of minimally invasive, small incision cataract surgery.
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