Fig. 7
From: Inhibition of miR-542-3p augments autophagy to promote diabetic corneal wound healing
miR-542-3p targeting of ATG4D influenced corneal nerve regeneration and epithelial healing in type 1 diabetes mellitus (T1DM) mice. a Corneal nerves whole-mount staining on day 5 of control mice (Ctrl), diabetic mice (DM), diabetic mice injected with miR-542-3p antagomir (DM + Ant-miR), diabetic mice injected with ATG4D ASO (DM + ATG4D ASO), and diabetic mice injected with miR-542-3p antagomir and ATG4D ASO (DM + Ant-miR + ATG4D ASO) after debridement (n = 6 per group). a1 Fluorescent images of corneal nerve staining. a2 Peripheral corneal nerve density. b Corneal sensation of each group on day 5 after debridement (n = 6 per group). c Corneas stained with fluorescein sodium of each group at 0, 12, 24, and 36 h after debridement (n = 6 per group). c1 Fluorescein-stained images of corneas. c2 Percentage of epithelial defect area. ns, P > 0.05; *, P < 0.05; ***, P < 0.001; ****, P < 0.0001