Fig. 1
From: Inhibition of miR-542-3p augments autophagy to promote diabetic corneal wound healing
Sustained hyperglycemia delayed corneal debridement healing in mice. a Flowchart for the establishment of type 1 diabetes mellitus (T1DM) mice and corneal debridement healing. b Blood glucose values of normal (Ctrl) and diabetic (DM) mice. b1 Blood glucose values at 0, 4, 8, 12, 16 weeks after intraperitoneal injection. b2 Significant differences in blood glucose levels between the two groups at 16 weeks. c Body weight values of Ctrl and DM mice at 16 weeks. d Corneal sensitivity of Ctrl and DM mice at 16 weeks. e Corneal nerves whole-mount staining on day 5 of Ctrl and DM mice after debridement (n = 6 per group). e1 Fluorescent images of corneal nerve staining. e2 Peripheral corneal nerve density. f Corneas stained with fluorescein sodium at 0, 12, 24, and 36 h in Ctrl and DM mice after debridement (n = 6 per group). f1 Fluorescein-stained images of corneas. f2 Percentage of epithelial defect area. *, P < 0.05; ***, P < 0.001; ****, P < 0.0001