Age-related changes in geometry and transparency of human crystalline lens revealed by optical signal discontinuity zones in swept-source OCT images

Table 2 Spearman’s correlation of measured parameters with age

Dependent variable	R_s	P value	FDR-corrected P value	Rate of change (per year)
Thickness (mm)
Lens	0.86*	< 0.001	< 0.001	0.023
Cortex	0.64*	< 0.001	< 0.001	0.017
Nucleus	0.34*	0.016	0.024	0.006
C1α	0.41*	0.003	0.007	0.001
C1β	0.25	0.083	0.101	0.0011
C2	− 0.02	0.892	0.892	− 0.0002
C3	0.70*	< 0.001	< 0.001	0.0146
C4	0.1	0.494	0.541	0.0006
Radius of curvature (mm)
Anterior lens capsule	− 0.70*	< 0.001	< 0.001	− 0.053
Anterior nucleus	− 0.67*	< 0.001	< 0.001	− 0.013
Posterior nucleus	− 0.30*	0.036	0.046	− 0.006
Posterior lens capsule	0.17	0.242	0.279	0.003
Optical density (a.u.)
Lens	0.76*	< 0.001	< 0.001	351
Cortex	0.42*	0.003	0.006	552
Nucleus	0.64*	< 0.001	< 0.001	101
C1α	− 0.37*	0.009	0.014	− 128
C1β	− 0.05	0.733	0.766	− 33
C2	0.45*	0.001	0.003	234
C3	0.74*	< 0.001	< 0.001	434
C4	0.56*	< 0.001	< 0.001	200
Objective scatter index	0.32*	0.025	0.034	0.014
Visual function
AULCSF	− 0.38*	0.007	0.013	0.0047
VA (logMAR)	0.37*	0.008	0.014	0.0005

FDR = false discovery rate; AULCSF = area under the log contrast sensitivity function; VA = visual acuity
Significance of Spearman’s correlation coefficient R_s was indicated with an asterisk

ISSN: 2326-0254