Skip to main content

Table 1 Diagnostic strategies and imaging tests in ectatic corneal diseases (ECD)

From: Multimodal diagnostics for keratoconus and ectatic corneal diseases: a paradigm shift

Diagnostic strategies

The Why’s

The How’s

Assess complaints

Recognize the patient’s needs and personal and family history

Anamnesis, visual acuity, slit-lamp exam, and comprehensive ophthalmological exam

Screening

Detect mild forms of ECD and characterize ectasia susceptibility before refractive surgery, contemplating the impact of LVC on the cornea

Placido-disk corneal topography, Scheimpflug tomography, Layered tomography with OCT (or VHF US), and biomechanical assessments

Diagnostic confirmation

Paradigm shift related to the management of ECD and access ectasia risk and progression

Comprehensive clinical evaluation with multimodal imaging

Classification of the type of ECD

Characterize the thinning pattern and pathophysiology of corneal ectasia

Integrating tomographic and biomechanical data with AI, possible future role for genetics and molecular biology

Staging

To assess the severity of the disease before visual loss

Belin´s “ABCD” (tomography) + biomechanical “E” (Homburg) for ectasia/KC staging

Prognostic

Patient counseling with education and management of ECD concerning the disease severity

Tomographic and biomechanical parameters (i.e., SPA-1), patient age, ocular allergy, and eye rubbing habit characterize

  1. ECD = ectatic corneal diseases; LVC = laser vision correction on the cornea; OCT = optical coherence tomography; VHF-US = very high-frequency ultrasound; AI = artificial intelligence; KC = keratoconus; SPA-1 = stiffness parameter at the first applanation