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Fig. 9 | Eye and Vision

Fig. 9

From: Homocysteine and mitochondrial quality control in diabetic retinopathy

Fig. 9

Working model. Diabetes elevates homocysteine and reduces H2S levels by impairing the transsulfuration pathway (inhibition of enzyme activities of Cbs and cystathionine γ-lyase, Cse). Presence of high homocysteine in hyperglycemic environment exacerbates and accelerates mitochondrial damage, and also decreases and slows down the removal of the damaged mitochondria (mitophagy), resulting in the exacerbation and acceleration of the development of diabetic retinopathy

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Eye and Vision

ISSN: 2326-0254