Fig. 8

Pan Eph receptor inhibitors demonstrate neuroprotective properties, preserving retinal ganglion cell dendritic arborization as observed by confocal microscopy following six days post optic nerve crush (ONC) injury. a Quantification of retinal ganglion cell dendritic arborization by Sholl analysis six days after ONC injury. Animals treated with 50 μM of UniPR129 (N = 3 biological replicates). 25% DMSO in phosphate buffered saline (PBS) was used as a vehicle control. b Quantification of retinal ganglion cell dendritic arborization by Sholl analysis six days after ONC injury. Animals treated with 2 μM of NVP-BHG712 (N = 3 biological replicates). 25% DMSO in PBS was used as a vehicle control. c Quantification of retinal ganglion cell dendritic arborization by Sholl analysis six days after ONC injury. Animals treated with a combination of both UniPR129 (50 μM) and NVP-BHG712 (2 μM) (N = 3 biological replicates are graphed; One biological replicate is depicted in the representative image). Mann–Whitney U tests and a P value of less than 0.05 is considered statistically significant. **P ≤ 0.01, ****P ≤ 0.0001. Scale bar at 50 μm