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Table 4 Risk for AMD due to multiplicative and additive interaction of GRS and mediSCORE

From: Interaction between genetics and the adherence to the Mediterranean diet: the risk for age-related macular degeneration. Coimbra Eye Study Report 8

Scale of interaction

Metric

Value (95% CI)

Multiplicative

OR

1.111 (0.346–3.569); P = 0.859

Additive

RERI = OR11 − OR01 − OR10 + 1

1.509 (− 0.414–3.432); P = 0.062

AP = RERI/OR11

0.326 (− 0.074–0.726); P = 0.055

SI=(OR11 − 1)/[(OR01 − 1) + (OR10 − 1)]

1.713 (0.098–3.329); P = 0.019

  1. AMD = age-related macular degeneration; OR = odds ratio; CI = confidence interval; GRS = genetic risk score; mediSCORE = adherence to the Mediterranean diet score; RERI = relative excess risk due to interaction; AP = attributable proportion; SI = synergy index
  2. Bold values represent statistically significant OR with P < 0.05
  3. OR01 refers to the risk for AMD of subjects with high adherence to the Mediterranean diet and high GRS
  4. OR10 refers to the risk for AMD of subjects with low adherence to the Mediterranean diet and low GRS
  5. OR11 refers to the risk for AMD of subjects with low adherence to the Mediterranean diet and high GRS
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Eye and Vision

ISSN: 2326-0254