Interaction between genetics and the adherence to the Mediterranean diet: the risk for age-related macular degeneration. Coimbra Eye Study Report 8

Table 3 Combined effects between mediSCORE and GRS on AMD risk (N = 1216 eyes)

	Low GRS (0)		High GRS (1)		OR^a (95% CI) for GRS within strata of mediSCORE
	N (cases/controls)	OR^a (95% CI)	N (cases/controls)	OR^a (95% CI)
High mediSCORE (0)	10/125	1.000 (reference)	13/91	1.788 (0.594–5.381) P = 0.301	2.037 (0.658–6.301) P = 0.217
Low mediSCORE (1)	83/390	2.327 (0.948–5.714) P = 0.065	145/359	4.624 (1.908–11.202) P < 0.001	1.980 (1.329–2.949) P < 0.001
ORs^a (95% CI) for mediSCORE within strata of GRS		2.296 (0.933–5.651) P = 0.070		2.589 (1.218–5.503) P = 0.013

AMD = age-related macular degeneration; OR = odds ratio; CI = confidence interval; GRS = genetic risk score; mediSCORE = adherence to the Mediterranean diet score; N = number of subjects
Bold values represent statistically significant OR with P < 0.05
^aORs (95% CIs) were estimated by using logistic regression model with generalized estimating equations (GEE) with individual eye as the unit of analysis, adjusted for age, sex, smoking and physical exercise. The reference category (high mediSCORE and low GRS) was chosen to assure that all factors are risk factors since additive measures were developed to use only with risk factors

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