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Table 2 Association of AMD with the GRS and the mediSCORE (N = 1216 eyes)

From: Interaction between genetics and the adherence to the Mediterranean diet: the risk for age-related macular degeneration. Coimbra Eye Study Report 8

Parameters

ORa

95% CI

P value

Genetic risk score

   

 Low GRS

1.000

–

Ref

 High GRS

1.963

1.344, 2.866

< 0.001

mediSCORE

   

 Low mediSCORE

1.000

–

Ref

 High mediSCORE

0.406

0.226, 0.728

0.002

Gender

   

 Female

1.000

–

Ref

 Male

0.514

0.329, 0.803

0.003

Age, years

   

 60–70 years

1.000

–

Ref

 70–75 years

1.467

0.887, 2.425

0.136

 > 75 years

2.839

1.806, 4.463

< 0.001

Physical exercise

   

 No

1.000

–

 

 Yes

0.688

0.465, 1.017

0.061

Smoking

   

 Non-smoker

1.000

–

 

 Smoker/ex-smoker

2.072

1.149, 3.736

0.015

  1. AMD = age-related macular degeneration; OR = odds ratio; CI = confidence interval; GRS = genetic risk score; mediSCORE = adherence to the Mediterranean diet score; ref = reference
  2. Bold values represent statistically significant OR with P < 0.05
  3. aORs (95% CIs) were estimated by using logistic regression model with generalized estimating equations (GEE) with individual eye as the unit of analysis, adjusted for age, sex, smoking and physical exercise. The reference categories in each variable are indicated in the table above as ref
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Eye and Vision

ISSN: 2326-0254