Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults

Su, Binbin; Zhu, Xiaoxuan; Yang, Kai; Xiao, Yunfan; Li, Chunmei; Shi, Keai; Qu, Jia; Lu, Fan; Li, Ming; Cui, Lele

doi:10.1186/s40662-022-00307-0

Eye and Vision

Table 2 Association of age with vessel density (multivariable analysis) of the whole study population

From: Age- and sex-related differences in the retinal capillary plexus in healthy Chinese adults

	Age group (years)
	20–29		30–39	40–49		50–59		≥ 60		P^b
	Adjusted β (95% CI)	P^a		Adjusted β (95% CI)	P^a	Adjusted β (95% CI)	P^a	Adjusted β (95% CI)	P^a	P^b
SCP
Whole	0.07 (− 0.50 to 0.64)	0.81	Ref.	− 0.03 (− 0.40 to 0.35)	0.90	− 0.96 (− 1.41 to − 0.50)	< 0.001	− 0.95 (− 1.72 to − 0.18)	0.02	< 0.001
Parafovea	− 0.03 (− 0.63 to 0.58)	0.94	Ref.	0.00 (− 0.40 to 0.40)	1.00	− 1.07 (− 1.56 to − 0.58)	< 0.001	− 0.87 (− 1.68 to − 0.05)	0.04	< 0.001
Temporal	0.01 (− 0.66 to 0.67)	0.98	Ref.	− 0.09 (− 0.53 to 0.36)	0.70	− 0.94 (− 1.47 to − 0.40)	< 0.001	− 1.03 (− 1.94 to − 0.12)	0.03	0.005
Superior	− 0.27 (− 0.93 to 0.39)	0.42	Ref.	− 0.13 (− 0.58 to 0.31)	0.56	− 1.36 (− 1.90 to − 0.82)	< 0.001	− 1.05 (− 1.95 to − 0.15)	0.02	< 0.001
Nasal	0.13 (− 0.55 to 0.81)	0.70	Ref.	0.11 (− 0.34 to 0.57)	0.63	− 0.81 (− 1.37 to − 0.26)	< 0.001	− 0.71 (− 1.63 to 0.22)	0.13	0.02
Inferior	0.02 (− 0.68 to 0.71)	0.97	Ref.	0.11 (− 0.35 to 0.58)	0.64	− 1.14 (− 1.71 to − 0.58)	< 0.001	− 0.73 (− 1.68 to 0.22)	0.13	0.001
DCP
Whole	− 0.24 (− 0.83 to 0.36)	0.43	Ref.	− 0.73 (− 1.13 to − 0.33)	< 0.001	− 1.45 (− 1.94 to − 0.97)	< 0.001	− 1.82 (− 2.63 to − 1.02)	< 0.001	< 0.001
Parafovea	− 0.37 (− 1.00 to 0.25)	0.25	Ref.	− 0.72 (− 1.14 to − 0.30)	< 0.001	− 1.58 (− 2.09 to − 1.07)	< 0.001	− 1.73 (− 2.58 to − 0.88)	< 0.001	< 0.001
Temporal	− 0.31 (− 0.93 to 0.32)	0.34	Ref.	− 0.70 (− 0.12 to − 0.28)	< 0.001	− 1.48 (− 1.99 to − 0.98)	< 0.001	− 1.76 (− 2.61 to − 0.90)	< 0.001	< 0.001
Superior	− 0.39 (− 1.13 to 0.36)	0.31	Ref.	− 0.92 (− 1.42 to − 0.43)	< 0.001	− 1.64 (− 2.25 to − 1.04)	< 0.001	− 1.84 (− 2.85 to − 0.83)	< 0.001	< 0.001
Nasal	− 0.18 (− 0.81 to 0.46)	0.59	Ref.	− 0.60 (− 1.03 to − 0.18)	0.01	− 1.69 (− 2.20 to − 1.17)	< 0.001	− 1.77 (− 2.63 to − 0.91)	< 0.001	< 0.001
Inferior	− 0.62 (− 1.36 to 0.12)	0.10	Ref.	− 0.65 (− 1.14 to − 0.16)	0.01	− 1.47 (− 2.06 to − 0.87)	< 0.001	− 1.59 (− 2.59 to − 0.59)	< 0.001	< 0.001

CI = confidence interval; SCP = superficial retinal capillary plexus; DCP = deep retinal capillary plexus; Ref. = reference. Adjusted for sex, education, current smoking status, current drinking status, body mass index, mean arterial pressure, axial length, and signal strength index of optical coherence tomography angiography image. ^aP values of each age group compared with the 30- to –39-year age group. ^bP values derived using multivariate generalized linear regression analysis

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