Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression

Table 3 Multiple regression analysis of factors associated with 1- and 2-year longitudinal changes in choroidal thickness in the central fovea

Factor	Subfoveal choroidal thickness change (µm)^a
Factor	One-year ∆thickness (95% CI)	P	Two-year ∆thickness (95% CI)	P
Age (years)	− 2.36 (− 5.74 to 1.01)	0.168	− 4.41 (− 8.81 to 0.01)	0.049
Sex	− 16.39 (− 24.13 to − 8.66)	< 0.001	− 17.25 (− 27.19 to − 7.32)	0.001
Lens	− 6.62 (− 14.44 to 1.18)	0.096	− 6.11 (− 16.02 to 3.79)	0.227
Baseline AL (mm)	− 8.87 (− 14.52 to − 3.21)	0.002	− 5.11 (− 12.30 to 2.07)	0.163
Baseline SER (D)	− 1.78 (− 7.66 to 4.09)	0.355	2.96 (− 4.48 to 10.40)	0.435
Baseline whole retinal thickness (µm)	− 0.25 (− 0.46 to 0.03)	0.024	− 0.19 (− 0.47 to 0.07)	0.158
Baseline subfoveal choroidal thickness (µm)	− 0.06 (− 0.12 to 0.01)	0.040	− 0.08 (− 0.16 to − 0.001)	0.046
One-year AL change (mm)	− 49.66 (− 79.68 to − 19.64)	0.001
Two-year AL change (mm)			− 43.58 (− 71.41 to − 15.74)	0.002
One-year SER change (D)	4.86 (− 5.22 to 14.95)	0.345
Two-year SER change (D)			9.08 (− 1.07 to 19.23)	0.080

CI= confidence interval; AL= axial length; SER= spherical equivalent of refraction
^a∆Thickness changes are based on estimates determined by regression analysis; lens includes three groups of lenses worn by the participants: personalized progressive addition lenses (PPALs), fixed progressive addition lenses (FPALs), and single vision lenses (SVLs)

ISSN: 2326-0254