Fig. 5

Loss-of-function of SUV39H1 remarkably retards corneal epithelial wound healing (CEWH) in mice. a Chaetocin dramatically delayed corneal epithelial wound closure. Representative images of fluorescein sodium-stained corneas in chaetocin and physiological saline treated groups are shown. b Histogram of residual epithelial defects of corneas in the chaetocin or physiological saline treated groups (n = 4/group). The remaining unrepaired areas are presented in pixels of size. c Repression of SUV39H1 expression markedly delayed corneal epithelial wound closure. Representative images are shown of fluorescein sodium-stained corneas in SUV39H1 siRNA or NC injected groups. d Histograms of residual epithelial defects of corneas in SUV39H1 siRNA and NC injected groups (n = 11/group). The remaining wound areas are presented in pixels of size