Visual acuity is correlated with ischemia and neurodegeneration in patients with early stages of diabetic retinopathy

Table 3 Comparison of retinal microvascular parameters and retinal sublayer or total thickness in control and diabetic groups after adjusting for age, duration of DM

	Control (G0)	DR With normal BCVA (G1)	DR with decreased BCVA (G2)	P All groups	P G0 vs. G1	P G0 vs. G2	P G1 vs. G2
Microvascular parameters
VD SRCP	0.056 ± 0.004	0.054 ± 0.005	0.052 ± 0.006	0.004	0.038	0.002	0.128
VD DRCP	0.072 ± 0.005	0.069 ± 0.006	0.062 ± 0.007	< 0.001	0.007	< 0.001	< 0.001
FAZ area (mm²)	0.325 ± 0.132	0.342 ± 0.117	0.401 ± 0.097	0.019	0.466	0.008	0.196
Retinal layer thickness
RNFL thickness (μm)	28.46 ± 2.88	30.04 ± 3.14	29.04 ± 3.64	0.214	0.082	0.272	0.849
GCL-IPL thickness (μm)	72.40 ± 5.59	73.62 ± 4.82	70.24 ± 6.21	0.112	0.653	0.182	0.033
INL thickness (μm)	17.52 ± 3.66	17.10 ± 3.41	17.10 ± 3.82	0.852	0.706	0.572	0.943
OPL thickness (μm)	10.15 ± 1.49	10.89 ± 2.51	10.60 ± 2.36	0.240	0.108	0.217	0.666
Total retinal thickness (μm)	239.46 ± 21.01	240.69 ± 16.13	236.31 ± 19.14	0.663	0.866	0.538	0.680

DM diabetes mellitus; BCVA best-corrected visual acuity; SRCP superficial retinal capillary plexus; DRCP deep retinal capillary plexus; VD vessel density; FAZ foveal avascular zone; RNFL retinal nerve fiber layer; GCL-IPL ganglion cell layer plus inner plexiform layer; INL inner nuclear layer; OPL outer plexiform layer
Bold font indicates significance of P < 0.05

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