Fig. 2
From: Anti-VEGF therapy prevents Müller intracellular edema by decreasing VEGF-A in diabetic retinopathy
Decrease in fluid accumulation by ranibizumab in the diabetic rat retina. a The morphology of normal control (left), diabetic (middle) and ranibizumab treated (right) rat retinas. b The ribbon-like transparent gaps, indicated by the arrows, demonstrate the swollen apical processes of Müller cells or their prolongations surrounding extracellular spaces. Müller intracellular edema was calculated as the number of ribbon-like transparent gaps per 200 μm of the retina. n = 6, * P < 0.05. N: normal control; D12w: 12-week diabetic retina; D + R: diabetic rat treated with ranibizumab. Scale bar: 50 μm