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Table 1 Study design, anti-viral regime, and steroid regime in studies on the management of CMV endotheliitis

From: Management of cytomegalovirus corneal endotheliitis

Study

Study location

Study design

No. of eyes (patients)

Anti-viral regime

Steroid regime

Mean duration of anti-viral treatmenta

Chee [48]

Singapore

retrospective interventional case series

12 (10)

5 patients

 • 6-week of intravenous ganciclovir 5 mg/kg twice daily

 • followed by 6 weeks of oral ganciclovir 1 g thrice daily

5 patients

 • 6 weeks of oral valganciclovir 900 mg twice daily

 • followed 6-week of oral ganciclovir 900 mg daily

topical prednisolone acetate 1% twice daily, tapered off over 3 months

12 weeks

Chiang [49]

Taiwan, China

case report

1 (1)

 • oral valganciclovir 900 mg twice daily

1-week of topical prednisolone 1% 4 times a day for 1 week

4 months

Choi [50]

South Korea

case report

1 (1)

 • 2 intravitreal ganciclovir injections (unspecific time interval between injections)

 • topical ganciclovir 0.15% every 2 h

topical prednisolone acetate 1% 4–6 times daily

N/A

Fan [51]

Taiwan, China

retrospective interventional case series

10 (9)

 • topical ganciclovir 0.5% every 2 h for 1 month, then tapered to 4 times per daily

topical prednisolone acetate 1% twice daily, then tapered to once or twice daily

48 months

Hwang [52]

Taiwan, China

case report

1 (1)

 • oral valganciclovir (details N/A)

topical prednisolone acetate 1% 4 times a day

2 months

Hwang [53]

Taiwan, China

retrospective interventional case series

13 (13)

 • topical ganciclovir 2% every 2 h for 2 weeks, then tapered to 4 times a day

topical prednisolone acetate 1% 4 times a day for 2 weeks, then tapered to twice daily

24.5 months

Kam [54]

Hong Kong, China

retrospective interventional case series

17 (16)

13 patients

 • oral valganciclovir 900 mg twice daily and topical ganciclovir ointment

3 patients

 • topical ganciclovir ointment

prednisolone acetate 1% ophthalmic suspension

12.5 months

Koizumi [55]

Japan

retrospective, consecutive, multicenter case series.

8 (8)

 • topical ganciclovir 0.15% 6 times per day

topical 0.1% fluorometholone eye drops 4 times daily

12 weeks

Pavan-Langston [56]

USA

case report

1 (1)

 • topical ganciclovir 0.15% every 2 h

topical prednisolone 1% once daily

4.5 months

Wong [57]

Hong Kong, China

retrospective interventional case series

13 (11)

 • 2-week loading dose of oral valganciclovir 900 mg twice daily

 • followed by 450 mg twice daily as maintenance

topical prednisolone acetate 1, 0.5% loteprednol etabonate eye drops, or 1% dexamethasone

ranging from 4 to 38 weeks

Yamauchi [58]

Japan

case report

1 (1)

 • 5 weeks oral valganciclovir 1800 mg/dayfollowed by 900 mg/day as maintenance

topical dexamethasone 0.1% 4 times a day

3 months

Yu [59]

China

retrospective interventional case series

16 (15)

 • oral ganciclovir 1000 mg/60 kg 3 times daily for 4 weeks

 • followed by 500 mg/60 kg 3 times daily for 8 weeks

 • multiple intravitreal ganciclovir injections (mean 3.47 injections)

 • topical ganciclovir 0.15% gel 4 times per day

topical prednisolone 0.1% 4 times daily with gradual tapering

N/A

  1. aincludes induction and maintenance period
  2. N/A = not available