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Table 1 Study design, anti-viral regime, and steroid regime in studies on the management of CMV endotheliitis

From: Management of cytomegalovirus corneal endotheliitis

Study Study location Study design No. of eyes (patients) Anti-viral regime Steroid regime Mean duration of anti-viral treatmenta
Chee [48] Singapore retrospective interventional case series 12 (10) 5 patients
 • 6-week of intravenous ganciclovir 5 mg/kg twice daily
 • followed by 6 weeks of oral ganciclovir 1 g thrice daily
5 patients
 • 6 weeks of oral valganciclovir 900 mg twice daily
 • followed 6-week of oral ganciclovir 900 mg daily
topical prednisolone acetate 1% twice daily, tapered off over 3 months 12 weeks
Chiang [49] Taiwan, China case report 1 (1)  • oral valganciclovir 900 mg twice daily 1-week of topical prednisolone 1% 4 times a day for 1 week 4 months
Choi [50] South Korea case report 1 (1)  • 2 intravitreal ganciclovir injections (unspecific time interval between injections)
 • topical ganciclovir 0.15% every 2 h
topical prednisolone acetate 1% 4–6 times daily N/A
Fan [51] Taiwan, China retrospective interventional case series 10 (9)  • topical ganciclovir 0.5% every 2 h for 1 month, then tapered to 4 times per daily topical prednisolone acetate 1% twice daily, then tapered to once or twice daily 48 months
Hwang [52] Taiwan, China case report 1 (1)  • oral valganciclovir (details N/A) topical prednisolone acetate 1% 4 times a day 2 months
Hwang [53] Taiwan, China retrospective interventional case series 13 (13)  • topical ganciclovir 2% every 2 h for 2 weeks, then tapered to 4 times a day topical prednisolone acetate 1% 4 times a day for 2 weeks, then tapered to twice daily 24.5 months
Kam [54] Hong Kong, China retrospective interventional case series 17 (16) 13 patients
 • oral valganciclovir 900 mg twice daily and topical ganciclovir ointment
3 patients
 • topical ganciclovir ointment
prednisolone acetate 1% ophthalmic suspension 12.5 months
Koizumi [55] Japan retrospective, consecutive, multicenter case series. 8 (8)  • topical ganciclovir 0.15% 6 times per day topical 0.1% fluorometholone eye drops 4 times daily 12 weeks
Pavan-Langston [56] USA case report 1 (1)  • topical ganciclovir 0.15% every 2 h topical prednisolone 1% once daily 4.5 months
Wong [57] Hong Kong, China retrospective interventional case series 13 (11)  • 2-week loading dose of oral valganciclovir 900 mg twice daily
 • followed by 450 mg twice daily as maintenance
topical prednisolone acetate 1, 0.5% loteprednol etabonate eye drops, or 1% dexamethasone ranging from 4 to 38 weeks
Yamauchi [58] Japan case report 1 (1)  • 5 weeks oral valganciclovir 1800 mg/dayfollowed by 900 mg/day as maintenance topical dexamethasone 0.1% 4 times a day 3 months
Yu [59] China retrospective interventional case series 16 (15)  • oral ganciclovir 1000 mg/60 kg 3 times daily for 4 weeks
 • followed by 500 mg/60 kg 3 times daily for 8 weeks
 • multiple intravitreal ganciclovir injections (mean 3.47 injections)
 • topical ganciclovir 0.15% gel 4 times per day
topical prednisolone 0.1% 4 times daily with gradual tapering N/A
  1. aincludes induction and maintenance period
  2. N/A = not available