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Table 5 Comparison of suggested cutoff values and their sensitivity and specificity levels for the diagnosis of keratoconus (KC) and KC suspect (KCS) in Down syndrome (DS) patients of the present study compared to non-DS young patients in other studies

From: Tomography-based definition of keratoconus for Down syndrome patients

  DS patients Non-DS patients
Cutoff Sensitivity (%) Specificity (%) Cutoff Sensitivity (%) Specificity (%)
KC Anterior HOA > 0.643 86.96 82.24 > 0.801 [20] 100.0 100.0
Posterior vertical coma > 0.0702 91.30 76.97 > 0.055 [20] 100.0 100.0
Anterior vertical coma > 0.4124 73.91 93.42 > 0.200 [21] 94.1 96.7
Total HOA > 0.608 95.65 67.76 > 0.908 [22] 86.5 81.1
KCS Minimum corneal thickness ≤ 480.0 66.67 90.91 < 512.0 [23] 64.0 58.0
Corneal volume ≤ 55.3 66.67 75.32 < 23.95 [24] 79.0 79.3
BAD-D > 2.23 64.58 76.32 > 1.6 [25] 83.8 86.0
  1. HOA = higher order aberrations; BAD-D = Belin Ambrosio display-total deviation