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Fig. 3 | Eye and Vision

Fig. 3

From: Genetic characterization of Stargardt clinical phenotype in South Indian patients using sanger and targeted sequencing

Fig. 3

Conservation analysis and structure prediction of wild-type and novel mutant ABCA4 proteins. a Multiple sequence alignment of human ABCA4 proteins with six different species (Danio rerio, Mus musculus, Sus scrofa, Pongo pygmaeus, Homo sapiens, Pan paniscus and Bos taurus) for identifying novel mutants revealed an alteration in a highly conserved amino acid - isoleucine to phenylalanine in case ID 25 and cysteine to phenylalanine in case ID 10. b Wild type and mutant type ABCA4 protein were predicted using I-TASSER online tool and viewed by PyMol version 2.3

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Eye and Vision

ISSN: 2326-0254