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Table 5 Outcomes reported in literature comparing different CXL procedures (2013–2015)

From: Collagen cross-linking: when and how? A review of the state of the art of the technique and new perspectives

Author (Year)

Techniques compared

Follow-up

Results

Type

Number of Eyes

Indication

   

Kmax

BCVA

   

NG AL et al. (2015) [106]

Standard vs accelerated

1 year

Reduction Kmax in standard group

Improvement BCVA in standard CXL

CIS

26

Keratoconus

Shetty R et al. (2015) [107]

Standard vs Different Accelerated Protocols

1 year

Improvement Kmax in standard and accelerated group

Improvement BCVA in Standard and accelerated CXL

PR

138

Keratoconus

Rossi S et al. (2015) [108]

Standard vs TE

1 year

Improvement Kmax in standard and TE CXL

Improvement BCVA in standard and TE CXL

PC

20

Keratoconus

Brittingham et al. (2014) [109]

Standard vs accelerated

1 year

Stabilization K max in standard CXL

 

RCS

131

Keratoconus

Hashemian H et al. (2014) [110]

Standard vs Accelerated

15 months

Improvement Kmax in standard and accelerated CXL

Improvement BCVA in Standard and accelerated CXL

RCT

153

Keratoconus

Sherif AM (2014) [111]

Standard vs Accelerated

1 year

Stabilization Kmax

Improvement BCVA in Standard and accelerated CXL

RCT

25

Keratoconus

Stojanovic A et al. (2014) [112]

Standard vs TE

1 year

Stabilization Kmax for standard and TE CXL

Improvement BCVA in standard and TE CXL

RCT

40

Keratoconus

Tomita M et al. (2014) [113]

Standard vs Accelerated

1 year

Improvement Kmax in standard and accelerated CXL

Improvement BCVA in Standard and accelerated CXL

PC

48

Keratoconus

Cinar Y et al. (2014) [114]

Standard vs Accelerated

6 months

Improvement Kmax in standard and accelerated CXL

Improvement BCVA in Standard and accelerated CXL

PC

26

Keratoconus

Magli A et al. (2013) [115]

Standard vs TE

1 year

Improvement K max in standard and TE CXL

Improvement BCVA in standard and TE CXL

PC

37

Keratoconus

  1. CIS= Comparative Interventional Study, PR= Prospective randomized, RCS= Retrospective case series, RCT= Randomized controlled trial, PC= Prospective comparative