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Table 4 Comparison of changes in RNFL features over time before and after registration

From: Effect of image registration on longitudinal analysis of retinal nerve fiber layer thickness of non-human primates using Optical Coherence Tomography (OCT)

RNFL feature Before registration After registration
Intercept (μm) Slope (μm/day) p value for slope Intercept (μm) Slope (μm/day) p value for slope
All rings 102.00393 −0.00257 0.8232 101.0946 0.0024 0.8543
Temporal 81.6539 0.0378 0.1412 83.1664 −0.0085 0.5937
Inferior 132.2164 −0.0081 0.6857 132.5075 0.0030 0.8902
Nasal 82.7397 −0.0167 0.4794 74.1178 0.0105 0.4744
Superior 112.1748 −0.0280 0.2417 110.8570 0.0030 0.8702
Clock hour 01 104.2529 −0.0684 0.0058* 100.3047 −0.0105 0.5423
Clock hour 02 89.6372 −0.0764 0.0054* 85.0136 −0.0238 0.1335
Clock hour 03 75.1912 −0.0156 0.4824 67.9575 0.0081 0.5795
Clock hour 04 83.2301 0.0345 0.4629 69.5369 0.0295 0.0806
Clock hour 05 129.4731 0.0205 0.5714 119.3772 0.0059 0.7964
Clock hour 06 141.3183 −0.0032 0.9131 144.1395 0.0044 0.8891
Clock hour 07 126.2726 −0.0456 0.2689 134.3108 −0.0003 0.9919
Clock hour 08 80.2741 −0.0248 0.4117 87.8058 −0.0183 0.3725
Clock hour 09 72.7352 0.0491 0.2124 69.7586 −0.0149 0.3827
Clock hour 10 92.0908 0.0901 0.0298* 92.1486 0.0085 0.6408
Clock hour 11 115.7404 0.0270 0.4125 113.4984 0.0235 0.3103
Clock hour 12 116.1991 −0.0349 0.2496 116.8135 −0.0010 0.9574
  1. A linear mixed effects model is used to estimate the change in RNFL features over time. Coefficients and the p values of the coefficients of the linear mixed effects model of RNFL features vs. days before registration and after registration by LPCC_MSBV algorithm are shown in this table. The intercept represents the magnitude of RNFL thickness and, therefore, the p values for intercepts are all zero indicating that the thickness is non-zero. The slopes represent the change of RNFL thickness features over time. The p values for the slopes are shown in the table.
  2. *p values were smaller than 0.05.