Table 4 Comparison of changes in RNFL features over time before and after registration

From: Effect of image registration on longitudinal analysis of retinal nerve fiber layer thickness of non-human primates using Optical Coherence Tomography (OCT)

RNFL feature	Before registration			After registration
RNFL feature	Intercept (μm)	Slope (μm/day)	p value for slope	Intercept (μm)	Slope (μm/day)	p value for slope
All rings	102.00393	−0.00257	0.8232	101.0946	0.0024	0.8543
Temporal	81.6539	0.0378	0.1412	83.1664	−0.0085	0.5937
Inferior	132.2164	−0.0081	0.6857	132.5075	0.0030	0.8902
Nasal	82.7397	−0.0167	0.4794	74.1178	0.0105	0.4744
Superior	112.1748	−0.0280	0.2417	110.8570	0.0030	0.8702
Clock hour 01	104.2529	−0.0684	0.0058*	100.3047	−0.0105	0.5423
Clock hour 02	89.6372	−0.0764	0.0054*	85.0136	−0.0238	0.1335
Clock hour 03	75.1912	−0.0156	0.4824	67.9575	0.0081	0.5795
Clock hour 04	83.2301	0.0345	0.4629	69.5369	0.0295	0.0806
Clock hour 05	129.4731	0.0205	0.5714	119.3772	0.0059	0.7964
Clock hour 06	141.3183	−0.0032	0.9131	144.1395	0.0044	0.8891
Clock hour 07	126.2726	−0.0456	0.2689	134.3108	−0.0003	0.9919
Clock hour 08	80.2741	−0.0248	0.4117	87.8058	−0.0183	0.3725
Clock hour 09	72.7352	0.0491	0.2124	69.7586	−0.0149	0.3827
Clock hour 10	92.0908	0.0901	0.0298*	92.1486	0.0085	0.6408
Clock hour 11	115.7404	0.0270	0.4125	113.4984	0.0235	0.3103
Clock hour 12	116.1991	−0.0349	0.2496	116.8135	−0.0010	0.9574

A linear mixed effects model is used to estimate the change in RNFL features over time. Coefficients and the p values of the coefficients of the linear mixed effects model of RNFL features vs. days before registration and after registration by LPCC_MSBV algorithm are shown in this table. The intercept represents the magnitude of RNFL thickness and, therefore, the p values for intercepts are all zero indicating that the thickness is non-zero. The slopes represent the change of RNFL thickness features over time. The p values for the slopes are shown in the table.
*p values were smaller than 0.05.

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