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Table 1 Demographic characteristics, AULCSF and OCTA parameters of the subjects

From: Reduced contrast sensitivity function correlated with superficial retinal capillary plexus impairment in early stage of dysthyroid optic neuropathy

Parameters

Control

non-DON

DON

P value*

P value1

P value2

P value3

N

24

50

31

–

–

–

–

Age (years)

45.2 ± 7.1

45.7 ± 8.8

48.1 ± 9.8

0.404

0.808

0.234

0.249

Sex (female/male)

17/7

32/18

22/9

0.752

0.561

0.991

0.518

SE (D)

− 0.86 ± 1.48

− 0.59 ± 1.41

− 0.17 ± 1.05

0.151

0.839

0.167

0.342

IOP (mmHg)

14.28 ± 1.58

16.70 ± 3.57

16.77 ± 3.85

0.008

0.001

0.006

1.000

Exophthalmometry (mm)

–

17.81 ± 3.10

18.85 ± 3.50

–

–

–

0.169

CAS

–

1.08 ± 0.85

1.43 ± 0.90

–

–

–

0.083

MI

–

0.60 ± 0.10

0.64 ± 0.11

–

–

–

0.146

Maximal MR diameter (mm)

–

6.51 ± 2.66

7.06 ± 2.13

–

–

–

0.388

BCVA (logMAR)

− 0.01 ± 0.03

− 0.00 ± 0.02

0.15 ± 0.07

< 0.001

0.598

< 0.001

< 0.001

MD (dB)

− 0.95 ± 1.15

− 1.10 ± 1.20

− 5.26 ± 3.81

< 0.001

0.935

< 0.001

< 0.001

AULCSF

1.31 ± 0.10

1.13 ± 0.15

0.88 ± 0.18

< 0.001

< 0.001

< 0.001

< 0.001

SRCP (%)

46.59 ± 1.72

45.01 ± 2.65

41.90 ± 3.35

< 0.001

0.009

< 0.001

< 0.001

DRCP (%)

50.07 ± 2.54

49.21 ± 3.01

48.74 ± 3.46

0.276

0.261

0.112

0.499

GCCL (μm)

103.55 ± 6.77

104.04 ± 7.41

97.53 ± 10.20

0.002

0.808

0.008

0.001

  1. Data are shown as mean ± standard deviation in each group
  2. Control = control eyes; DON = dysthyroid optic neuropathy; non-DON = TAO patients without clinical signs of DON; TAO = thyroid-associated ophthalmopathy; SE = spherical equivalent refractive error; IOP = intraocular pressure; CAS = clinical activity score; MI = muscle index; MR = medial rectus; BCVA = best-corrected visual acuity; MD = mean deviation of visual field; AULCSF = area under the log contrast sensitivity function; SRCP = superficial retinal capillary plexus; DRCP = deep retinal capillary plexus; GCCL = ganglion cell complex layer; – = not performed
  3. P value* = P value among the three groups; P value1 = P value between the control and non-DON groups; P value2 = P value between the control and DON groups; P value3 = P value between the non-DON and DON groups