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Table 1 Results of selected clinical studies of the MicroShunt device

From: Subconjunctival filtration in evolution: current evidence on MicroShunt implantation for treating patients with glaucoma

Author,

year

Study design

Follow-up (years)

No. of eyes/no. of patients

MMC dose (mg/mL)

IOP (mmHg)a

No. of medicationsa

Baseline

At follow-up

Baseline

At follow-up

Riss et al. 2015 [12]

Retrospective, two-center, two-surgeon

1

23/23

0.4

near limbus

23.8 ± 5.3

10.7 ± 2.8

2.4 ± 0.9

0.3 ± 0.8

31/31

0.2

near limbus

27.9 ± 6.7

13.3 ± 3.3

2.5 ± 1.4

0.5 ± 1.0

33/33

0.4

deep in pocket

25.4 ± 7.9

15.7 ± 4.6

2.9 ± 1.0

0.8 ± 1.3

Batlle et al. 2016 [13]

Single-center case series

3

23/23

0.4

23.8 ± 5.3

10.7 ± 3.5

2.4 ± 0.9

0.7 ± 1.1

Batlle et al. 2021 [14]

Single-center case series

5

23/23

0.4

23.8 ± 5.3

12.4 ± 6.5

2.4 ± 1.0

0.8 ± 1.3

Ahmed et al. 2022 [15]

Single-center, non-randomized

6

8/7

Not stated

17.9 ± 3.5

13.5 ± 3.1

3.5 ± 0.5

2.0 ± 1.1

Schlenker et al. 2020 [16]

Retrospective case series

1

164/132

0.2–0.5

20 (IQR 16.5–26)

12 (IQR 10–15)

4 (IQR 3–4)

0 (IQR 0–0)

Durr et al. 2022 [17]

Retrospective cohort

1

85/79

Not stated

22 (IQR 18–29)

13 (IQR 10–17)

4 (IQR 3–4)

0 (IQR 0–2)

Baker et al. 2021 [18]

Prospective randomized controlled trial

1

MicroShunt group 395/395

0.2

21.1 ± 4.9

14.3 ± 4.3

3.1 ± 1.0

0.6 ± 1.1

Trabeculectomy group 132/132

0.2

21.1 ± 5.0

11.1 ± 4.3

3.0 ± 0.9

0.3 ± 0.9

Panarelli et al. 2021 [19]

Prospective randomized controlled trial

2

MicroShunt group 395/395

0.2

21.1 ± 4.9

13.9 ± 3.9

3.1 ± 1.0

0.9 ± 1.3

Trabeculectomy group 132/132

0.2

21.1 ± 5.0

10.7 ± 3.7

2.9 ± 0.9

0.4 ± 0.9

Beckers et al. 2022 [20]

Prospective, multi-center, single-arm

2

81/81

0.2–0.4

21.7 ± 3.4

14.1 ± 3.2

2.1 ± 1.3

0.5 ± 0.9

  1. IQR = interquartile range; IOP = intraocular pressure; MMC = mitomycin C
  2. aMean ± standard deviation values reported, except for Schlenker et al. (2020) and Durr et al. (2022) which report median values