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Table 2 Association of SNPs from ANGPT2 in NTG, HTG and POAG adjusted for age and sex

From: Genetic association of ANGPT2 with primary open-angle glaucoma

SNP

Nucleotide change

Risk allele

RAF

HTG vs. Control

NTG vs. Control

POAG vs. Control

HTG (n = 484)

NTG (n = 537)

POAG (n = 1021)

Control (n = 496)

Pnon-adjusted

Non-adjusted OR (95% CI)

Padjusted

Adjusted OR (95% CI)

Pnon-adjusted

Non-adjusted OR (95% CI)

Padjusted

Adjusted OR (95% CI)

Pnon-adjusted

Non-adjusted OR (95% CI)

Padjusted

Adjusted OR (95% CI)

Hong Kong

 rs2515487

c.289-10440C>A

A

0.240

0.238

0.239

0.239

0.950

1.01 (0.82–1.24)

0.815

1.03 (0.82–1.28)

0.977

1.00 (0.81–1.22)

0.761

1.03 (0.84–1.28)

0.986

1.00 (0.84–1.20)

0.704

1.04 (0.86–1.25)

 rs13255574

c.289-8669C>T

C

0.789

0.789

0.789

0.762

0.148

1.17 (0.95–1.45)

0.367

1.11 (0.89–1.38)

0.148

1.16 (0.95–1.43)

0.118

1.19 (0.96–1.47)

0.093

1.17 (0.97–1.40)

0.173

1.14 (0.95–1.37)

 rs4455855

c.289-7422T>A

A

0.300

0.29

0.295

0.293

0.740

1.03 (0.85–1.26)

0.833

1.02 (0.83–1.26)

0.850

0.98 (0.81–1.19)

0.739

1.03 (0.85–1.26)

0.943

1.01 (0.85–1.19)

0.882

1.01 (0.85–1.21)

 rs13269021

c.289-6755G>T

G

0.543

0.54

0.541

0.523

0.389

1.08 (0.90–1.29)

0.715

1.04 (0.86–1.25)

0.441

1.07 (0.90–1.27)

0.446

1.07 (0.90–1.29)

0.348

1.08 (0.92–1.25)

0.542

1.05 (0.90–1.23)

 rs11775442

c.289-6350A>G

A

0.782

0.796

0.789

0.764

0.354

1.11 (0.89–1.37)

0.558

1.07 (0.86–1.33)

0.083

1.20 (0.98–1.48)

0.0498*

1.24 (1.00–1.55)

0.119

1.16 (0.96–1.38)

0.149

1.15 (0.95–1.39)

Shantou

 rs2515487

c.289-10440C>A

A

0.286

0.282

0.285

0.286

0.981

1.00 (0.82–1.23)

0.995

1.00 (0.76–1.31)

0.908

0.98 (0.73–1.32)

0.971

1.01 (0.71–1.43)

0.989

1.00 (0.83–1.21)

0.916

0.99 (0.78–1.26)

 rs2922869

c.289-9785T>C

T

0.729

0.727

0.727

0.704

0.251

1.13 (0.92–1.39)

0.439

1.12 (0.85–1.47)

0.458

1.12 (0.83–1.52)

0.529

1.12 (0.78–1.60)

0.247

1.12 (0.92–1.36)

0.407

1.11 (0.87–1.42)

 rs13255574

c.289-8669C>T

C

0.785

0.782

0.782

0.763

0.276

1.13 (0.91–1.42)

0.320

1.16 (0.86–1.57)

0.530

1.11 (0.80–1.54)

0.607

1.11 (0.75–1.63)

0.297

1.12 (0.91–1.37)

0.380

1.13 (0.86–1.46)

 rs4455855

c.289-7422T>A

A

0.323

0.308

0.319

0.330

0.735

0.97 (0.79–1.18)

0.776

0.96 (0.74–1.25)

0.503

0.91 (0.68–1.21)

0.633

0.92 (0.66–1.29)

0.576

0.95 (0.79–1.14)

0.558

0.93 (0.74–1.18)

 rs13269021

c.289-6755G>T

G

0.584

0.626

0.594

0.500

0.354

1.09 (0.91–1.32)

0.217

1.17 (0.91–1.49)

0.059

1.31 (0.99–1.73)

0.183

1.25 (0.90–1.72)

0.137

1.14 (0.96–1.36)

0.142

1.18 (0.95–1.47)

 rs11775442

c.289-6350A>G

A

0.808

0.788

0.802

0.796

0.535

1.07 (0.86–1.35)

0.357

1.15 (0.85–1.55)

0.803

0.96 (0.70–1.32)

0.915

1.02 (0.70–1.49)

0.734

1.04 (0.84–1.28)

0.586

1.08 (0.83–1.40)

  1. CI = confidence interval; HTG = high tension glaucoma; NTG = normal tension glaucoma; OR = odds ratio; POAG = primary open-angle glaucoma; RAF = risk allele frequency
  2. Pnon-adjusted = P values derived from the χ2 test
  3. Padjusted = P values derived from logistic regression models after adjusting for age and sex
  4. *P value < 0.05
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