Peripapillary structural and microvascular alterations in early dysthyroid optic neuropathy

Table 2 Comparisons of the ONH-wiVD and RPC-VD among control and TAO patients

	Regions	Control	NDON	EDON	DON	P value	Post hoc analysis P values
	Regions	Control	NDON	EDON	DON	P value	C vs. N	C vs. E	N vs. E
ONH-wiVD (%)	Whole	57.43 ± 2.68	56.86 ± 1.81	56.22 ± 3.42	53.98 ± 3.90	< 0.001	0.373	0.086	0.365
	Inside disc	61.70 ± 3.65	59.92 ± 4.39	60.69 ± 3.97	57.28 ± 5.17	< 0.001	0.058	0.324	0.454
	Peripapillary	59.74 ± 2.61	59.41 ± 2.05	58.23 ± 3.71	56.55 ± 4.69	< 0.001	0.645	0.054	0.133
	Superior-hemi	60.21 ± 3.05	59.59 ± 2.03	58.55 ± 3.65	56.76 ± 4.54	< 0.001	0.388	0.037	0.194
	Inferior-hemi	59.28 ± 2.43	59.18 ± 2.30	57.89 ± 3.90	56.26 ± 4.99	0.001	0.892	0.088	0.115
RPC-VD (%)	Whole	50.66 ± 2.50	50.14 ± 1.77	49.20 ± 3.28	47.42 ± 3.70	< 0.001	0.376	0.025	0.160
	Inside disc	52.07 ± 4.67	49.67 ± 5.03	49.40 ± 4.74	47.13 ± 5.67	< 0.001	0.023	0.022	0.818
	Peripapillary	53.24 ± 2.61	53.04 ± 2.53	51.38 ± 3.71	50.20 ± 4.58	< 0.001	0.768	0.016	0.038
	Superior-hemi	53.29 ± 2.99	53.02 ± 2.63	51.47 ± 3.62	50.29 ± 4.75	0.001	0.711	0.024	0.061
	Inferior-hemi	53.17 ± 2.57	52.75 ± 2.27	51.27 ± 4.07	50.12 ± 4.66	< 0.001	0.547	0.015	0.067

Data are presented as mean ± standard deviation for all subjects in each group. Control or C = control eyes; TAO = thyroid-associated ophthalmopathy; DON = dysthyroid optic neuropathy; NDON or N = non-DON; EDON or E = equivocal DON; ONH-wiVD = optic nerve head whole image vessel density; RPC-VD = radial peripapillary capillary vessel density; – = not performed; NA = not applicable. P values in bold indicate statistical significance

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