Table 1 Summary of the pre- and post-treatment clinical data

OSDI

37.6 (16.6)

34.7 (5.0 to 78.0)

22.6 (14.6)

18.3 (0.0 to 50.0)

SPEED score

13.0 (4.9)

12.5 (6.0 to 25.0)

7.3 (4.8)

6.0 (0.0 to 22.0)

SANDE frequency score

63.8 (22.5)

72.5 (10.0 to 100.0)

37.8 (24.2)

34.2 (0.0 to 95.0)

SANDE severity score

58.6 (22.9)

59.2 (10.0 to 94.1)

35.3 (21.7)

30.0 (0.0 to 85.0)

Symptomatology VAS

5.9 (2.1)

5.5 (1.0 to 10.0)

4.1 (1.7)

4.0 (1.0 to 7.0)

Bulbar hyperemia grading

1.6 (0.5)

1.5 (0.9 to 3.4)

1.4 (0.5)

1.3 (0.5 to 2.3)

Nasal limbar hyperemia grading

1.2 (0.6)

1.1 (0.4 to 2.7)

1.1 (0.5)

0.9 (0.3 to 2.2)

Temporal limbar hyperemia grading

1.3 (0.4)

1.3 (0.4 to 1.9)

1.1 (0.6)

1.0 (0.4 to 2.9)

Oxford staining score

8.9 (2.7)

9.0 (5.0 to 15.0)

6.9 (2.3)

7.0 (3.0 to 12.0)

Tear film osmolarity (mOsm/l)

330.1 (21.1)

328.5 (279.0 to 378.0)

313.8 (21.6)

317.0 (249.0 to 353.0)

Meiboscore

2.4 (0.6)

2.0 (1.0 to 4.0)

2.2 (0.7)

2.0 (1.0 to 4.0)

Meibomian gland expressibility

2.4 (0.5)

2.0 (2.0 to 3.0)

2.1 (0.4)

2.0 (1.0 to 3.0)

Tear film meniscus (μm)

288.5 (169.4)

242.5 (100.0 to 781.0)

229.9 (112.0)

208.5 (129.0 to 710.0)

First break NIBUT

6.0 (3.7)

5.3 (2.1 to 17.4)

7.4 (3.8)

6.7 (1.9 to 15.1)

Average NIBUT

13.2 (4.6)

14.2 (4.2 to 21.6)

14.0 (5.1)

15.3 (2.0 to 21.5)