Fig. 5
From: Transcription factor Foxp1 is essential for the induction of choroidal neovascularization
Foxp1 KO reduces leakage of fluorescein sodium in the laser-induced choroidal neovascularization (CNV). a Fundus fluorescein angiography (FFA) images in control (Foxp1fl/flSix3-Cre−) and KO mice (Foxp1fl/fl Six3-Cre+) at 5 and 10 min after intraperitoneal injection of fluorescein sodium at day 6 post-laser injury. Fluorescence in the CNV spots was increased at 10 min from that at 5 min. b Percentage of the increase in fluorescence intensity (FI), which was quantified from FFA at 10 over 5 min. c The level of leakage was assessed by leakage grading. Grade 0: not leaky; Grade 1: questionable leakage; Grade 2a: leaky; Grade 2b: pathologically significant leakage. The pathological leakage was reduced in the KO mice. **: P < 0.01, n = 4, Student’s t-test