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Table 4 Summary of literature review for image enhancement (denoising and super-resolution) tasks using GAN in ophthalmology imaging domains

From: Application of generative adversarial networks (GAN) for ophthalmology image domains: a survey

Publication

Basic technique

Domain

Target

Summary

Halupka et al. [48]

Modified Wasserstein GAN + perceptual loss (conditional GAN)

Retinal OCT (spectral domain)

Removing speckle noise

The GAN was used to reduce speckle artifacts in retinal OCT images. The method improved the image quality metrics for OCT

Mahapatra et al. [55]

PGGAN with a conditional design

Fundus photography

Super-resolution

Image super-resolution using multi-stage PGGAN outperforms competing methods and baseline GANs. The super-resolved images can be used for landmark and pathology detection

Huang et al. [49]

Conditional GAN

Retinal OCT

Super-resolution and removing noise

The GAN model effectively suppressed speckle noise and super-resolved OCT images at different scales

Ouyang et al. [51]

Conditional GAN

Anterior Segment OCT

Removing speckle noise

The model removed undesired specular artifacts and speckle-noise patterns to improve the visualization of corneal and limbal OCT images

Yoo et al. [53]

CycleGAN

Fundus photography

Removing artifacts and noise

The GAN model removed the artifacts automatically in a fundus photograph without matching paired images

Cheong et al. [16]

DeshadowGAN (modified conditional GAN with perceptual loss)

Peripapillary retinal OCT (spectral domain)

Removing vessel shadow artifacts

The GAN model using manually masked artifact images and perceptual loss function removed blood vessel shadow artifacts from OCT images of the optic nerve head

Chen et al. [50]

Conditional GAN

Peripapillary retinal OCT (spectral domain)

Removing speckle noise

The GAN model was designed for speckle noise reduction in OCT images and preserved the textural details found in OCT

Das et al. [52]

CycleGAN

Retinal OCT

Super-resolution and removing noise

To achieve denoising and super-resolution, adversarial learning with cycle consistency was used without requiring aligned low–high resolution pairs

Ha et al. [56]

Enhanced super-resolution GAN (SRGAN)

Peripapillary fundus photography (optic disc photo)

Super-resolution

The GAN approach was capable of 4-times up-scaling and enhancement of anatomical details using contrast, color, and brightness improvement

Yuhao et al. [54]

CycleGAN

Fundus photography

Removing artifacts and noise

The developed model dehazed cataractous retinal images through unpaired clear retinal images and cataract images

  1. GAN = generative adversarial network; OCT = optical coherence tomography; PGGAN = progressively growing GAN