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Table 2 Longitudinal parameters of 168 participants at baseline and follow-up visits

From: Two-year longitudinal change in choroidal and retinal thickness in school-aged myopic children: exploratory analysis of clinical trials for myopia progression

Parameterc,d

Baseline

One-year follow-up

Two-year follow-up

ΔThickness

F

P

SER (D)

− 2.39 (− 2.75, − 2.00)

− 3.41 (− 4.00, − 2.87)

− 3.88 (− 4.50, − 3.25)

798.16

< 0.001

AL (mm)

24.58 (24.04, 25.08)

24.94 (24.43, 25.44)

25.24 (24.71, 25.71)

1113.87

< 0.001

Retina (µm)

251.12 ± 15.91a

251.09 ± 16.34b

253.47 ± 15.74a,b

23.785

< 0.001

RNFL (µm)

14.47 ± 1.96a

14.93 ± 2.23a,b

14.31 ± 2.31a

3.652

0.027

GCL + IPL (µm)

24.34 ± 5.96

24.31 ± 5.85

24.63 ± 6.07

1.407

0.352

HFL + ONL (µm)

88.29 ± 10.67a,b

90.74 ± 10.92a

90.16 ± 10.49b

10.262

< 0.001

Choroid (µm)

 Central

231.03 ± 54.04

223.71 ± 56.76

206.53 ± 59.71

24.63 ± 31.16

66.635

< 0.001

 Para-N

197.44 ± 55.73

190.25 ± 57.16

175.36 ± 61.67

22.08 ± 26.61

81.990

< 0.001

 Para-T

241.78 ± 53.88

229.81 ± 53.11

216.47 ± 60.57

24.30 ± 33.89

58.673

< 0.001

 Para-S

233.09 ± 50.10

228.39 ± 54.66

214.97 ± 56.65

18.11 ± 34.06

32.074

< 0.001

 Para-I

236.17 ± 54.42

228.91 ± 58.02

212.57 ± 61.23

23.59 ± 32.39

59.813

< 0.001

 Peri-N

155.47 ± 49.74

152.75 ± 50.89

139.12 ± 52.79

16.35 ± 22.65

61.377

< 0.001

 Peri-T

244.04 ± 53.80

234.45 ± 52.27

221.23 ± 60.11

22.81 ± 38.93

38.841

< 0.001

 Peri-S

232.69 ± 51.47

231.60 ± 52.17

221.48 ± 56.13

11.20 ± 38.41

11.048

< 0.001

 Peri-I

229.81 ± 53.64

224.72 ± 54.80

212.03 ± 59.96

17.77 ± 31.45

35.879

< 0.001

  1. ΔThickness, change in choroidal thickness between the baseline and the 2-year follow-up
  2. SER= spherical equivalent of refraction; D= dioptre; AL= axial length; RNFL= retinal nerve fibre layer; GCL + IPL= ganglion cell layer and inner plexiform layer; HFL + ONL= Henle fibre layer and outer nuclear layer; Para= parafoveal; Peri= perifoveal; N= nasal; T= temporal; S= superior; I= inferior
  3. a,bThe same superscript letter indicate a significant difference between the two results after pairwise comparison using Bonferroni correction
  4. cMedians (interquartile range) for SER and AL
  5. dThe means ± standard deviations for RNFL, GCL + IPL, HFL + ONL, retina, and choroid