Skip to main content

Table 1 Summary of baseline visit visual acuity data and ulcer size, epithelization times in both treatment groups, and mean follow-up time and visual acuities at discharge visit

From: PACK-CXL vs. antimicrobial therapy for bacterial, fungal, and mixed infectious keratitis: a prospective randomized phase 3 trial

Baseline visit Medication group (n = 21) PACK-CXL group (n = 18) P-value
Mean (SD) Mean (SD)
Ulcer size (mm) 2.33 (0.87) 2.75 (1.07) 0.1564
UCVA (logMAR) 1.15 (1.03) 1.24 (0.90) 0.494
CDVA (logMAR) 0.73 (0.85) 0.76 (0.66) 0.453
Epithelization time (days) Medication group (n = 19) PACK-CXL group (n = 16) P-value
Median 7 7 0.828
Q75% 20.5 10  
Q90% 37 19.6  
Maximum 50 28  
Mean (SD) 14.58 (14.95) 9.94 (7.18)  
Epithelization time difference between both groups
Difference (PACK-CXL-med) − 4.64   
Pooled SD 12.06   
Error margin 8.02   
CI (95%) (− 12.66, 3.38)   
Discharge visit Medication group (n = 19) PACK-CXL group (n = 16) P-value
Mean (SD) Mean (SD)
Therapy/follow-up duration (days) 29.42 (12.60) 22.56 (3.82)  
UCVA (logMAR) 1.00 (1.06) 0.79 (0.68) 0.96
CDVA (logMAR) 0.54 (0.75) 0.53 (0.68) 0.96
  1. UCVA uncorrected visual acuity; CDVA corrected distance visual acuity; logMAR logarithm of the minimum angle of resolution; med medication group, PACK-CXL photoactivated chromophore corneal cross-linking; SD standard deviation; CI confidence interval