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Table 3 Eight-year outcomes in visual field mean deviation, cup-to-disc ratio, retinal nerve fiber layer thickness, and ganglion cell-inner plexiform layer thickness

From: Long-term outcomes of two first-generation trabecular micro-bypass stents (iStent) with phacoemulsification in primary open-angle glaucoma: eight-year results

Variable N Mean % Change vs. baseline Mean change vs. baseline P value
VF-MD (dB)
 Preoperative 58 − 5.9 ± 6.6    
 POY1 52 − 4.1 ± 5.8 − 30.5 1.8 0.092
 POY2 46 − 4.7 ± 6.0 − 20.3 1.2 0.130
 POY3 47 − 6.3 ± 6.5 6.8 − 0.4 0.227
 POY4 46 − 5.8 ± 6.3 − 1.7 0.1 0.953
 POY5 45 − 5.5 ± 6.4 − 6.8 0.4 0.634
 POY6 44 − 7.0 ± 7.1 18.6 − 1.1 0.027*
 POY7 45 − 6.6 ± 7.3 11.9 − 0.7 0.043*
 POY8 57 − 8.0 ± 7.8 35.6 − 2.1  < 0.001**
CDR
 Preoperative 42 0.71 ± 0.16    
 POY1 45 0.71 ± 0.16 0.0 0.00 0.751
 POY2 52 0.70 ± 0.17 − 1.4 − 0.01 0.203
 POY3 49 0.70 ± 0.17 − 1.4 − 0.01 0.322
 POY4 48 0.70 ± 0.16 − 1.4 − 0.01 0.310
 POY5 48 0.70 ± 0.16 − 1.4 − 0.01 0.187
 POY6 47 0.71 ± 0.16 0.0 0.00 0.830
 POY7 45 0.71 ± 0.15 0.0 0.00 0.782
 POY8 53 0.70 ± 0.16 − 1.4 − 0.01 0.176
RNFL thickness (μm)
 Preoperative 14 70.5 ± 13.7    
 POY1 19 71.7 ± 11.3 1.7 1.2 0.613
 POY2 35 74.4 ± 13.5 5.5 3.9 0.205
 POY3 36 74.7 ± 12.6 6.0 4.2 0.214
 POY4 39 74.8 ± 11.3 6.1 4.3 0.192
 POY5 42 74.7 ± 12.0 6.0 4.2 0.222
 POY6 41 74.6 ± 12.6 5.8 4.1 0.230
 POY7 40 75.2 ± 12.2 6.7 4.7 0.181
 POY8 49 74.3 ± 11.9 5.4 3.8 0.228
GC-IPL thickness (μm)
 Preoperative 14 64.4 ± 12.9    
 POY1 19 65.7 ± 11.2 2.0 1.3 0.623
 POY2 34 65.6 ± 13.1 1.9 1.2 0.674
 POY3 36 64.2 ± 11.9 − 0.3 − 0.2 0.962
 POY4 39 67.4 ± 11.2 4.7 3.0 0.337
 POY5 42 65.5 ± 11.5 1.7 1.1 0.679
 POY6 41 64.2 ± 12.5 − 0.3 − 0.2 0.966
 POY7 40 65.1 ± 11.4 1.1 0.7 0.752
 POY8 48 63.8 ± 10.9 − 0.9 − 0.6 0.857
  1. VF-MD visual field mean deviation; CDR cup-to-disc ratio; RNFL retinal nerve fiber layer; GC-IPL ganglion cell-inner plexiform layer; POM postoperative month; POY postoperative year
  2. Mean ± Standard deviations are presented and statistically compared to preoperative values using Generalized Estimating Equations with sequential Bonferroni correction for multiple comparisons. Statistical significance is denoted by * for P < 0.05 and ** for P < 0.001