Table 4 Two-way ANOVA with tests of between-subjects effects for all variables tested, estimated marginal means and pairwise comparison for the IOP dependent variable and intergroup t-test comparison between Preserflo Microshunt with MMC 0.2 mg/ml and Preserflo Microshunt with MMC 0.2 mg/ml and Ologen implantation
From: Preliminary results of Preserflo Microshunt versus Preserflo Microshunt and Ologen implantation
Two-way ANOVA | |||||||
|---|---|---|---|---|---|---|---|
Levene’s test for equality of error variances | |||||||
F | DF 1 | DF 2 | P | ||||
3.9319 | 11 | 271 | < 0.001 | ||||
Tests of between-subjects effects (all variables) | |||||||
Source | Sum of squares | DF | Mean square | F | Partial eta squared | Observed powerb | P |
Follow up | 9514.47 | 5 | 1902.89 | 98.70 | 0.639 | 1.0 | < 0.001 |
Intervention | 36.31 | 1 | 36.31 | 1.88 | 0.06 | 0.27 | 0.17 |
Follow up*Intervention | 64.22 | 5 | 12.84 | 0.66 | 0.01 | 0.25 | 0.64 |
Residual | 5224.34 | 271 | 19.27 | ||||
Estimated marginal means (IOP dependent) | |||||||
Follow up | n | Mean | Std. Error | 95% Confidence interval | |||
Baseline | 50 | 24.78 | 0.62 | 23.54 to 26.01 | |||
1 Day | 50 | 7.37 | 0.62 | 6.13 to 8.60 | |||
2 Weeks | 50 | 9.48 | 0.62 | 8.24 to 10.71 | |||
1 Month | 50 | 10.12 | 0.62 | 8.89 to 11.36 | |||
3 Months | 50 | 10.98 | 0.62 | 9.74 to 12.21 | |||
6 Months | 50 | 12.18 | 0.71 | 10.78 to 13.58 | |||
Follow up | Intervention | n | Mean ± SD | Std. Error | t-test (P) | 95% Confidence interval | |
Baseline | Group A | 25 | 23.52 ± 5.88 | 0.87 | 0.26 | 21.79 to 25.24 | |
Group B | 25 | 26.04 ± 8.76 | 0.89 | 24.27 to 27.80 | |||
1 Day | Group A | 25 | 7.24 ± 3.47 | 0.87 | 0.76 | 5.51 to 8.96 | |
Group B | 25 | 7.50 ± 4.23 | 0.89 | 5.73 to 9.26 | |||
2 Weeks | Group A | 25 | 8.88 ± 3.08 | 0.87 | 0.34 | 7.15 to 10.60 | |
Group B | 25 | 10.08 ± 5.48 | 0.89 | 8.31 to 11.84 | |||
1 Month | Group A | 25 | 9.92 ± 3.25 | 0.87 | 0.49 | 8.19 to 11.64 | |
Group B | 25 | 10.33 ± 2.53 | 0.89 | 8.56 to 12.09 | |||
3 Months | Group A | 25 | 11.20 ± 2.71 | 0.89 | 0.63 | 9.44 to 12.97 | |
Group B | 25 | 10.76 ± 2.78 | 0.87 | 9.03 to 12.48 | |||
6 Months | Group A | 25 | 12.00 ± 3.13 | 0.63 | 0.89 | 10.01 to 13.98 | |
Group B | 25 | 12.36 ± 3.37 | 0.67 | 10.38 to 14.35 | |||
Pairwise comparisons (IOP dependent) | Mean difference | Std. Error | P a | 95% CI a | |||
Baseline | 1 Day | 17.41 | 0.88 | < 0.0001 | 14.78 to 20.03 | ||
2 Weeks | 15.29 | 0.88 | < 0.0001 | 12.67 to 17.92 | |||
1 Month | 14.65 | 0.88 | < 0.0001 | 12.02 to 17.28 | |||
3 Months | 13.79 | 0.88 | < 0.0001 | 11.16 to 16.42 | |||
6 Months | 12.59 | 0.94 | < 0.0001 | 9.78 to 15.40 | |||
1 Day | Baseline | −17.41 | 0.88 | < 0.0001 | −20.03 to −14.78 | ||
2 Weeks | −2.11 | 0.88 | 0.27 | −4.73 to 0.51 | |||
1 Month | −2.75 | 0.88 | 0.0314 | −5.38 to −0.12 | |||
3 Months | −3.61 | 0.88 | 0.0009 | −6.24 to −0.98 | |||
6 Months | −4.81 | 0.94 | < 0.0001 | −7.62 to −2.00 | |||
Pairwise comparisons (IOP dependent) | Mean difference | Std. Error | P a | 95% CI a | |||
2 Weeks | Baseline | −15.29 | 0.88 | < 0.0001 | − 17.92 to −12.67 | ||
1 Day | 2.11 | 0.88 | 0.27 | − 0.51 to 4.73 | |||
1 Month | −0.64 | 0.88 | 1.00 | −3.27 to 1.98 | |||
3 Months | −1.50 | 0.88 | 1.00 | −4.13 to 1.12 | |||
6 Months | −2.70 | 0.94 | 0.07 | −5.51 to 0.10 | |||
1 Month | Baseline | −14.65 | 0.88 | < 0.0001 | −17.28 to −12.02 | ||
1 Day | 2.75 | 0.88 | 0.0314 | 0.12 to 5.38 | |||
2 Weeks | 0.64 | 0.88 | 1.00 | −1.98 to 3.27 | |||
3 Months | −0.85 | 0.88 | 1.00 | −3.48 to 1.77 | |||
6 Months | −2.05 | 0.94 | 0.46 | −4.86 to 0.75 | |||
3 Months | Baseline | −13.79 | 0.88 | < 0.0001 | −16.42 to −11.16 | ||
1 Day | 3.61 | 0.88 | 0.0009 | 0.98 to 6.24 | |||
2 Weeks | 1.50 | 0.88 | 1.00 | −1.12 to 4.13 | |||
1 Month | 0.85 | 0.88 | 1.00 | −1.77 to 3.48 | |||
6 Months | −1.20 | 0.94 | 1.00 | −4.01 to 1.61 | |||
6 Months | Baseline | −12.59 | 0.94 | < 0.0001 | −15.40 to −9.78 | ||
1 Day | 4.81 | 0.94 | < 0.0001 | 2.00 to 7.62 | |||
2 Week | 2.70 | 0.94 | 0.07 | −0.10 to 5.51 | |||
1 Month | 2.05 | 0.94 | 0.46 | −0.75 to 4.86 | |||
3 Months | 1.20 | 0.94 | 1.00 | −1.61 to 4.01 | |||