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Table 2 Comparison of the Top 10 DCR and pachymetric parameters between healthy and KC subjects in order of its importance in classification models

From: Development of a classification system based on corneal biomechanical properties using artificial intelligence predicting keratoconus severity

  Healthy Keratoconus P value Mild KC Moderate KC Advanced KC P value* P value P value
ARTh 533 ± 95 236 ± 126 < 0.001 348 ± 128 227 ± 75 132 ± 50 < 0.001 < 0.001 < 0.001
InverseR (mm-1) 0.17 ± 0.04 0.23 ± 0.04 < 0.001 0.20 ± 0.02 0.23 ± 0.03 0.26 ± 0.04 < 0.001 < 0.001 < 0.001
SPA1 (mmHg/mm) 109.5 ± 15.3 68.9 ± 18.9 < 0.001 82.6 ± 13.5 69.3 ± 15.6 54.5 ± 16.0 < 0.001 < 0.001 < 0.001
Pachyslope (μm) 43.1 ± 8.1 72.8 ± 29.5 < 0.001 52.6 ± 12.7 69.2 ± 19.4 97.1 ± 33.0 0.003 < 0.001 < 0.001
Pachy (μm) 564 ± 26 487 ± 42 < 0.001 513 ± 30 491 ± 34 458 ± 43 < 0.001 < 0.001 < 0.001
IntInversR (mm-1) 8.2 ± 1.1 11.7 ± 2.5 < 0.001 9.8 ± 1.3 11.7 ± 1.6 13.8 ± 2.5 < 0.001 < 0.001 < 0.001
DAR2 (mm) 4.20 ± 0.44 5.76 ± 1.14 < 0.001 4.98 ± 0.61 5.66 ± 0.73 6.64 ± 1.30 < 0.001 < 0.001 < 0.001
DAR1 (mm) 1.57 ± 0.06 1.71 ± 0.08 < 0.001 1.65 ± 0.06 1.71 ± 0.07 1.76 ± 0.08 < 0.001 < 0.001 < 0.001
Radius (mm) 7.27 ± 0.83 5.66 ± 0.96 < 0.001 6.43 ± 0.74 5.59 ± 0.69 4.95 ± 0.82 < 0.001 < 0.001 < 0.001
A1DefA (mm) 0.10 ± 0.01 0.11 ± 0.02 < 0.001 0.10 ± 0.01 0.11 ± 0.01 0.12 ± 0.02 0.151 0.002 < 0.001
  1. * Between Healthy and mild KC; Between mild KC and moderate KC; Between moderate KC and advanced KC. A1 applanation 1; ARTh Ambrosio relational thickness horizontal; DAR1/2 ratio of central and peripheral deformation at 1/2 mm; DefA deflection amplitude; InverseR inverse concave radius; IntInversR integrated inverse (concave) radius, Pachy corneal thickness measured by Corvis ST; Radius anterior corneal curvature from 2-dimensional corneal cross-section by Corvis ST; SPA1 stiffness parameter at 1st applanation. Bold type signifies P < 0.05