Development of a classification system based on corneal biomechanical properties using artificial intelligence predicting keratoconus severity

Table 2 Comparison of the Top 10 DCR and pachymetric parameters between healthy and KC subjects in order of its importance in classification models

	Healthy	Keratoconus	P value	Mild KC	Moderate KC	Advanced KC	P value*	P value^†	P value^‡
ARTh	533 ± 95	236 ± 126	< 0.001	348 ± 128	227 ± 75	132 ± 50	< 0.001	< 0.001	< 0.001
InverseR (mm^-1)	0.17 ± 0.04	0.23 ± 0.04	< 0.001	0.20 ± 0.02	0.23 ± 0.03	0.26 ± 0.04	< 0.001	< 0.001	< 0.001
SPA1 (mmHg/mm)	109.5 ± 15.3	68.9 ± 18.9	< 0.001	82.6 ± 13.5	69.3 ± 15.6	54.5 ± 16.0	< 0.001	< 0.001	< 0.001
Pachyslope (μm)	43.1 ± 8.1	72.8 ± 29.5	< 0.001	52.6 ± 12.7	69.2 ± 19.4	97.1 ± 33.0	0.003	< 0.001	< 0.001
Pachy (μm)	564 ± 26	487 ± 42	< 0.001	513 ± 30	491 ± 34	458 ± 43	< 0.001	< 0.001	< 0.001
IntInversR (mm^-1)	8.2 ± 1.1	11.7 ± 2.5	< 0.001	9.8 ± 1.3	11.7 ± 1.6	13.8 ± 2.5	< 0.001	< 0.001	< 0.001
DAR2 (mm)	4.20 ± 0.44	5.76 ± 1.14	< 0.001	4.98 ± 0.61	5.66 ± 0.73	6.64 ± 1.30	< 0.001	< 0.001	< 0.001
DAR1 (mm)	1.57 ± 0.06	1.71 ± 0.08	< 0.001	1.65 ± 0.06	1.71 ± 0.07	1.76 ± 0.08	< 0.001	< 0.001	< 0.001
Radius (mm)	7.27 ± 0.83	5.66 ± 0.96	< 0.001	6.43 ± 0.74	5.59 ± 0.69	4.95 ± 0.82	< 0.001	< 0.001	< 0.001
A1DefA (mm)	0.10 ± 0.01	0.11 ± 0.02	< 0.001	0.10 ± 0.01	0.11 ± 0.01	0.12 ± 0.02	0.151	0.002	< 0.001

* Between Healthy and mild KC; ^† Between mild KC and moderate KC; ^‡ Between moderate KC and advanced KC. A1 applanation 1; ARTh Ambrosio relational thickness horizontal; DAR1/2 ratio of central and peripheral deformation at 1/2 mm; DefA deflection amplitude; InverseR inverse concave radius; IntInversR integrated inverse (concave) radius, Pachy corneal thickness measured by Corvis ST; Radius anterior corneal curvature from 2-dimensional corneal cross-section by Corvis ST; SPA1 stiffness parameter at 1st applanation. Bold type signifies P < 0.05

ISSN: 2326-0254