Table 4 Multivariate regression analysis of associations with lens power stratified by age of 75 years and AL of 25 mm

Variables Age (years) AL (mm)
50 ≤ Age < 75, N = 3180 Age ≥ 75, N = 590 AL < 25, N = 3350 AL ≥ 25, N = 420
Estimate, 95% CI p value Estimate, 95% CI p value Estimate, 95% CI p value Estimate, 95% CI p value
Age −0.103 (−0.114, −0.092) < 0.001 −0.056 (−0.105, −0.008) 0.023 −0.080 (−0.088, −0.071) < 0.001 −0.077 (−0.107, −0.046) < 0.001
Sex 0.224 (0.061, 0.387) 0.007 0.027 (−0.497, 0.552) 0.918 0.124 (−0.036, 0.284) 0.127 0.312 (−0.207, 0.830) 0.238
Type 2 DM 0.591 (0.477, 0.705) < 0.001 0.286 (−0.076, 0.647) 0.122 0.506 (0.395, 0.617) < 0.001 0.260 (−0.114, 0.635) 0.172
AL −0.722 (−0.778, −0.666) < 0.001 −0.982 (−1.216, −0.748) < 0.001 −1.487 (−1.585, −1.389) < 0.001 −0.225 (−0.388, −0.062) 0.007
LT 1.132 (0.934, 1.331) < 0.001 1.153 (0.592, 1.715) < 0.001 1.133 (0.943, 1. 322) < 0.001 1.205 (0.571, 1.839) < 0.001
ACD −0.623 (−0.843, −0.403) < 0.001 0.017 (−0.681, −0.715) 0.962 0.094 (−0.132, 0.319) 0.415 −1.113 (−1.782, −0.444) 0.001
CP −0.195 (−0.238, −0.152) < 0.001 −0.272 (−0.408, −0.136) < 0.001 −0.409 (−0.456, −0.362) < 0.001 −1.133 (−0.260, −0.006) 0.040
Height −0.023 (−0.033, −0.013) < 0.001 −0.022 (−0.051, 0.008) 0.151 −0.019 (−0.028, −0.009) < 0.001 −0.019 (−0.049, 0.011) 0.212
IOP 0.026 (0.007, 0.045) 0.008 −0.032 (−0.091, 0.027) 0.289 0.012 (−0.006, 0.030) 0.201 0.008 (−0.058, 0.074) 0.819
Advanced cataract 0.210 (0.012, 0.407) 0.037 0.535 (0.164, 0.907) 0.005 0.401 (0.232, 0.571) < 0.001 0.505 (0.001, 1.009) 0.050
1. Multivariate regression analysis was used to explore the relationship between lens power and Type 2 DM after adjusting for age, sex, AL, LT, ACD, CP, height, IOP, and advanced cataract in subgroups stratified by age of 75 years and AL of 25 mm. R2 for age < 75 years: 0.435; R2 for age ≥ 75 years: 0.244; R2 for AL < 25 mm: 0.408; R2 for AL ≥ 25 mm: 0.182
2. ACD = anterior chamber depth; AL = axial length; CI = confidence intervals; CP = corneal power; D = diopter; DM = diabetic mellitus; IOP = intraocular pressure; LT = lens thickness; SD = standard deviation; SE = spherical equivalents