Impact of ablation ratio on 5-year postoperative posterior corneal stability after refractive surgery: SMILE and FS-LASIK

Li, Meiyan; Yang, Danjuan; Zhao, Yu; Yang, Weiming; Shang, Jianmin; Zhou, Xueyi; Yao, Peijun; Yang, Dong; Lin, Xue; Zhou, Xingtao

doi:10.1186/s40662-020-00218-y

Eye and Vision

Table 2 Parameters associated with posterior corneal elevation at 6-month and 5-year follow-up

From: Impact of ablation ratio on 5-year postoperative posterior corneal stability after refractive surgery: SMILE and FS-LASIK

Univariate analysis								Multivariate analysis
6-month follow-up		PCE		PTE		PME		6-month follow-up	PCE		PTE		PME
Parameters		Correlation coefficient	P value	Correlation coefficient	P value	Correlation coefficient	P value	Parameters	Correlation coefficient	P value	Correlation coefficient	P value	Correlation coefficient	P value
Sex	Male	−1.32 ± 3.01	< 0.05	−0.48 ± 2.74	< 0.05	−0.24 ± 1.85	0.98	Sex (Male vs. Female)	−1.99 ± 0.74	0.01	−2.15 ± 0.72	0.003	NS	0.84
Sex	Female	1.13 ± 4.23	< 0.05	2.04 ± 4.32	< 0.05	−0.25 ± 1.93	0.98	Sex (Male vs. Female)	−1.99 ± 0.74	0.01	−2.15 ± 0.72	0.003	NS	0.84
Age	≥20	−2.00 ± 2.28	0.16	0.80 ± 1.64	0.09	−2.67 ± 3.21	0.13	Age	0.19 ± 0.07	0.003	0.19 ± 0.07	0.01	NS	1.00
	21 ~ 30	0.05 ± 4.28		1.00 ± 4.30		−0.04 ± 1.97
	31 ~ 40	0.67 ± 3.83		1.30 ± 3.72		−0.39 ± 1.54
	≥41	3.50 ± 3.42		4.88 ± 3.94		−0.36 ± 1.66
Surgical group	FS-LASIK	1.34 ± 4.21	0.23	2.09 ± 4.00	0.35	0.03 ± 1.88	0.04	Surgical group (SMILE vs. FS-LASIK)	NS	0.26	NS	0.36	NS	0.42
Surgical group	SMILE	0.26 ± 4.21	0.23	1.23 ± 4.37	0.35	−0.82 ± 1.82	0.04	Surgical group (SMILE vs. FS-LASIK)	NS	0.26	NS	0.36	NS	0.42
Ablation ratio^a	High-level	0.69 ± 4.43	0.87	1.69 ± 4.43	0.7	−0.35 ± 1.79	0.63	Ablation ratio	NS	0.76	NS	0.82	NS	0.90
Ablation ratio^a	Low-level	0.55 ± 4.08	0.87	1.36 ± 4.14	0.7	−0.16 ± 1.98	0.63	Ablation ratio	NS	0.76	NS	0.82	NS	0.90
5-year follow-up		PCE		PTE		PME		5-year follow-up	PCE		PTE		PME
Sex	Male	1.38 ± 4.97	0.6	2.07 ± 5.26	0.95	0.28 ± 2.26	0.38	Gender (Male vs. Female)	NS	0.81	NS	0.90	NS	0.78
Sex	Female	0.76 ± 5.75	0.6	1.99 ± 6.20	0.95	−0.15 ± 2.25	0.38	Gender (Male vs. Female)	NS	0.81	NS	0.90	NS	0.78
Age	≥20	2.43 ± 3.55	0.23	3.57 ± 3.21	0.24	1.23 ± 1.90	< 0.001	Age	NS	0.31	NS	0.28	−0.13 ± 0.04	0.001
	21 ~ 30	1.46 ± 5.23		2.55 ± 5.70		0.44 ± 1.99
	31 ~ 40	0.13 ± 4.16		1.39 ± 4.79		−0.59 ± 2.24
	≥41	−1.73 ± 10.27		−1.00 ± 10.42		−2.35 ± 2.38
Surgical group	FS-LASIK	1.63 ± 5.83	0.18	2.74 ± 6.13	0.22	−0.01 ± 2.21	0.83	Surgical group (SMILE vs. FS-LASIK)	NS	0.75	NS	0.80	NS	0.88
Surgical group	SMILE	0.30 ± 5.25	0.18	1.42 ± 5.78	0.22	−0.01 ± 2.27	0.83	Surgical group (SMILE vs. FS-LASIK)	NS	0.75	NS	0.80	NS	0.88
Ablation ratio^a	High-level	2.33 ± 4.68	< 0.05	3.38 ± 4.88	< 0.05	0.20 ± 2.03	0.25	Ablation ratio	2.68 ± 1.05	0.01	2.35 ± 1.17	0.04	NS	0.48
Ablation ratio^a	Low-level	−0.56 ± 5.99	< 0.05	0.61 ± 6.64	< 0.05	−0.28 ± 2.40	0.25	Ablation ratio	2.68 ± 1.05	0.01	2.35 ± 1.17	0.04	NS	0.48

^aHigh and low-level were divided by median ablation ratio in univariate analysis. Parameters with P value less than 0.1 in any one of follow-ups were entered into a multivariable analysis using generalized estimating equations. SMILE= small incision lenticule extraction; FS-LASIK=femtosecond laser-assisted in situ keratomileusis; PCE=posterior central elevation; PTE=posterior corneal surface at thinnest point; PME=posterior corneal mean elevation; NS=not significant. P values less than 0.05 were considered statistically significant

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