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Fig. 7 | Eye and Vision

Fig. 7

From: The anti-scarring effect of corneal stromal stem cell therapy is mediated by transforming growth factor β3

Fig. 7

The anti-fibrotic effect of hCSSC on mouse stromal wound model was reduced by TGFβ3 knockdown. Fresh wounds were treated with hCSSC or hCSSC-TGFβ3(si). a After 14 days, intense scar was formed in corneas treated with hCSSC-TGFβ3(si), but not with naïve CSSC. b Scar intensity measurement showed that corneas treated with hCSSC-TGFβ3(si) had significantly greater scar intensities than those with naïve hCSSC. The levels were similar as in the sham control after wounding. c Mouse scar tissue genes (Col3a1 and αSMA) were suppressed after treatment of naïve hCSSC but remained elevated for hCSSC-TGFβ3(si) treatment. d Other mouse fibrotic genes (FN1, HAS2, SPARC and TNC) were also elevated in corneas with hCSSC-TGFβ3(si) treatment, but not with naïve hCSSC. Mean and SD are calculated from triplicate experiments. b **P < 0.05, Mann-Whitney U test. c, d *P < 0.05, paired Student’s t-test

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Eye and Vision

ISSN: 2326-0254