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Fig. 6 | Eye and Vision

Fig. 6

From: The anti-scarring effect of corneal stromal stem cell therapy is mediated by transforming growth factor β3

Fig. 6

The anti-inflammatory effect of hCSSC on mouse stromal wound model was attenuated by TGFβ3 knockdown. After cell treatment for 1 day, mouse specific early inflammatory genes (CD80, CXCL5, Lcn2, PLAUR, Ppbp and Spp1) were upregulated in the wounded corneas, as compared to naïve corneas. Gene expression was suppressed by hCSSC treatment, representing an anti-inflammatory effect. Such a response was attenuated when hCSSC-TGFβ3(si) were applied. Mean and SD represent data from triplicate experiments. *P < 0.05, paired Student’s t-test

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Eye and Vision

ISSN: 2326-0254