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Table 2 Results of discriminant analysis in differentiating between DS-KC (n = 46 eyes) and DS-C (n = 154 eyes) groups

From: Tomography-based definition of keratoconus for Down syndrome patients

Index

AUROC

Cutoff

Sensitivity (%)

Specificity (%)

Correct classification (%)

Anterior HOA

0.879

> 0.643

86.96

82.24

82.86

Posterior vertical coma

0.875

> 0.0702

91.30

76.97

78.86

Anterior vertical coma

0.868

> 0.4124

73.91

93.42

90.86

Total HOA

0.867

> 0.608

95.65

67.76

71.43

Total vertical coma

0.852

> 0.3665

73.91

89.47

87.43

I-S value

0.851

> 1.13

84.00

83.77

83.80

IVA

0.846

> 0.26

80.00

79.22

79.33

ISV

0.821

> 39.0

56.00

91.56

86.59

IHD

0.807

> 0.027

56.00

91.56

86.59

KI

0.806

> 1.05

84.00

64.94

67.60

BAD-D

0.802

> 2.45

70.83

84.21

82.39

ARC

0.768

≤ 7.19

64.00

83.12

80.45

PRC

0.754

≤ 5.91

68.00

79.22

77.65

ZKmax

0.751

> 47.34

68.00

75.16

74.16

Kmax

0.741

> 49.91

48.00

94.81

88.27

Anterior horizontal coma

0.722

> 0.3102

78.26

59.87

61.45

Total horizontal coma

0.719

> 0.323

78.26

61.18

63.43

Ksteep

0.702

> 48.50

52.00

87.66

82.68

Anterior elevation at thinnest point

0.696

> 8.0

48.00

94.74

88.13

Posterior elevation at thinnest point

0.689

> 14.0

60.00

85.53

81.92

  1. HOA = higher order aberrations; I-S value = inferior-superior asymmetry; IVA = index of vertical asymmetry; ISV = index of surface variance; IHD = index of height decentration; KI = keratoconus index; BAD-D = Belin Ambrosio display-total deviation; ARC = anterior radius of curvature centered on thinnest point; PRC = posterior radius of curvature centered on thinnest point; ZKmax = maximum keratometry in a 3 mm zone around the steepest point; Kmax = Maximum keratometry at 8 mm; Ksteep = maximum keratometry at central 3 mm