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Table 2 Results of discriminant analysis in differentiating between DS-KC (n = 46 eyes) and DS-C (n = 154 eyes) groups

From: Tomography-based definition of keratoconus for Down syndrome patients

Index AUROC Cutoff Sensitivity (%) Specificity (%) Correct classification (%)
Anterior HOA 0.879 > 0.643 86.96 82.24 82.86
Posterior vertical coma 0.875 > 0.0702 91.30 76.97 78.86
Anterior vertical coma 0.868 > 0.4124 73.91 93.42 90.86
Total HOA 0.867 > 0.608 95.65 67.76 71.43
Total vertical coma 0.852 > 0.3665 73.91 89.47 87.43
I-S value 0.851 > 1.13 84.00 83.77 83.80
IVA 0.846 > 0.26 80.00 79.22 79.33
ISV 0.821 > 39.0 56.00 91.56 86.59
IHD 0.807 > 0.027 56.00 91.56 86.59
KI 0.806 > 1.05 84.00 64.94 67.60
BAD-D 0.802 > 2.45 70.83 84.21 82.39
ARC 0.768 ≤ 7.19 64.00 83.12 80.45
PRC 0.754 ≤ 5.91 68.00 79.22 77.65
ZKmax 0.751 > 47.34 68.00 75.16 74.16
Kmax 0.741 > 49.91 48.00 94.81 88.27
Anterior horizontal coma 0.722 > 0.3102 78.26 59.87 61.45
Total horizontal coma 0.719 > 0.323 78.26 61.18 63.43
Ksteep 0.702 > 48.50 52.00 87.66 82.68
Anterior elevation at thinnest point 0.696 > 8.0 48.00 94.74 88.13
Posterior elevation at thinnest point 0.689 > 14.0 60.00 85.53 81.92
  1. HOA = higher order aberrations; I-S value = inferior-superior asymmetry; IVA = index of vertical asymmetry; ISV = index of surface variance; IHD = index of height decentration; KI = keratoconus index; BAD-D = Belin Ambrosio display-total deviation; ARC = anterior radius of curvature centered on thinnest point; PRC = posterior radius of curvature centered on thinnest point; ZKmax = maximum keratometry in a 3 mm zone around the steepest point; Kmax = Maximum keratometry at 8 mm; Ksteep = maximum keratometry at central 3 mm