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Table 4 Demographics of top 5 variables listed in the Fisher’s scoring system using different variables from Pentacam HR model and UHR-OCT model to discriminate sub-clinical KC group from normal group

From: Machine learning helps improve diagnostic ability of subclinical keratoconus using Scheimpflug and OCT imaging modalities

  Mean ± SD Intragroup Comparison
Normal Sub KC KC Normal vs. Sub KC Normal vs. KC
Features     P  
Pentacam & UHR-OCT Model
 EPV (μm) b 2.8 ± 0.7 4.1 ± 1.0 6.8 ± 2.5 <  0.001 <  0.001
 BPV (μm) b 1.3 ± 0.3 1.7 ± 0.5 2.6 ± 1.0 <  0.001 <  0.001
 EMax (back) (mm) a 4.8 ± 2.5 11.1 ± 7.4 28.5 ± 10.3 <  0.001 <  0.001
 ISV a 17.2 ± 5.9 24.5 ± 8.3 91.0 ± 37.2 <  0.001 <  0.001
 KI a 1.02 ± 0.03 1.05 ± 0.03 1.21 ± 0.12 <  0.001 <  0.001
Pentacam Model
 IVA 0.1 ± 0.1 0.2 ± 0.1 0.8 ± 0.4 <  0.001 <  0.001
 Ecenter (back) (mm) −0.6 ± 2.2 1.9 ± 5.0 14.7 ± 10.6 0.012 <  0.001
UHR-OCT Model
 EPSD (μm) 3.3 ± 1.1 4.4 ± 1.2 7.9 ± 2.4 <  0.001 <  0.001
 BEI-MAX (I/S) (μm) 78.6 ± 5.4 63.6 ± 23.4 50.0 ± 14.4 0.001 <  0.001
 BMIN (I) (μm) 15.2 ± 1.5 12.4 ± 4.5 9.4 ± 2.6 0.001 <  0.001
  1. a Included in the UHR-OCT model. b Included in the Pentacam model. Sub KC= subclinical keratoconus group; KC= keratoconus group; UHR-OCT= ultra-high resolution optical coherence tomography; EPV= profile variation of epithelium; BPV= profile variation of Bowman’s layer; Emax (back): max elevation of 5 mm best-fit sphere of back corneal surface. ISV= index of surface variance; KI= keratoconus index; IVA= index of vertical asymmetry; Ecenter (back): central elevation of 5 mm best-fit sphere of back corneal surface; EPSD = epithelium profile standard deviation; BEI-MAX: maximum ectasia index of Bowman’s layer; Bmin (I): the thinnest thickness of the inferior Bowman’s layer thickness map