Fig. 6
From: Automated diagnosis and staging of Fuchs’ endothelial cell corneal dystrophy using deep learning
Qualitative discrimination between healthy cornea (a), early-stage Fuchs’ endothelial corneal dystrophy (FECD) (b), and late-stage FECD (c) in AS-OCT images. Healthy and early-stage FECD do not have clinically evident edema on slit-lamp examination (SLE) as shown in the OCT image, yet early FECD demonstrates thickening of the endothelial/Descemet complex (En/DM). Late-stage FECD shows obvious edema with subepithelial bullae. The presets display magnified images of the posterior section of the corresponding cornea. In healthy cornea, the En/DM was visualized as a band formed by 2 smooth regular hyper-reflective lines with a hyporeflective space in between. In FECD, the posterior line had a wavy irregular appearance with areas of focal excrescences representing guttae (white arrows). Figure (d) shows a frame from the early stage FECD eye that was misclassified as late-stage FECD. Note the undulations in the endothelial/Descemet complex and a small vesicle underneath the Bowman’s layer