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Table 3 Comparisons of the RCDs in the superficial and deep retinal capillary layers among controls and TAO patients with and without DON

From: Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy

Layers

Regions

Control (C)

Non-DON (N)

DON (D)

P Value (C vs. N)

P Value (C vs. D)

P Value (N vs. D)

SRCL (%)

TAZ

63.7 ± 3.3

60.0 ± 3.5

59.8 ± 4.5

< 0.001

< 0.001

0.807

C1

57.6 ± 12.9

48.5 ± 14.6

51.1 ± 11.6

0.003

0.033

0.382

C2

63.0 ± 5.6

60.6 ± 5.8

60.8 ± 5.2

0.069

0.092

0.869

C3

64.0 ± 4.5

61.0 ± 4.3

61.2 ± 5.5

0.008

0.011

0.867

C4

64.4 ± 3.7

61.4 ± 4.0

60.3 ± 5.3

0.003

< 0.001

0.326

C5

64.8 ± 3.1

60.8 ± 3.8

60.9 ± 5.0

< 0.001

< 0.001

0.899

C6

64.2 ± 2.9

61.4 ± 3.6

60.0 ± 4.4

0.001

< 0.001

0.127

S

63.4 ± 3.9

60.3 ± 4.3

60.0 ± 5.3

0.004

0.001

0.789

T

64.0 ± 3.5

61.2 ± 4.2

60.3 ± 5.0

0.005

< 0.001

0.385

I

63.7 ± 3.6

59.7 ± 4.0

59.5 ± 5.6

< 0.001

< 0.001

0.857

N

63.6 ± 4.3

59.0 ± 4.0

59.5 ± 4.5

< 0.001

< 0.001

0.652

DRCL (%)

TAZ

73.9 ± 4.8

70.2 ± 4.4

66.4 ± 7.7

0.007

< 0.001

0.006

C1

40.6 ± 18.8

34.0 ± 16.2

29.7 ± 15.3

0.096

0.006

0.277

C2

71.6 ± 8.5

66.7 ± 8.4

61.3 ± 12.4

0.039

< 0.001

0.020

C3

78.3 ± 4.1

75.2 ± 4.3

71.9 ± 7.5

0.016

< 0.001

0.013

C4

78.4 ± 4.0

75.9 ± 3.6

72.3 ± 7.4

0.045

< 0.001

0.004

C5

77.8 ± 3.6

74.4 ± 3.9

71.3 ± 7.7

0.007

< 0.001

0.017

C6

76.5 ± 4.2

72.9 ± 4.1

68.9 ± 8.1

0.009

< 0.001

0.004

S

75.0 ± 4.6

71.2 ± 4.1

68.0 ± 8.1

0.008

< 0.001

0.020

T

73.4 ± 4.7

69.4 ± 5.1

65.1 ± 9.2

0.011

< 0.001

0.007

I

75.0 ± 4.9

71.5 ± 4.9

67.7 ± 7.0

0.009

< 0.001

0.005

N

72.4 ± 5.7

68.8 ± 4.6

64.8 ± 7.9

0.017

< 0.001

0.007

  1. RCD = retinal capillary density; TAO = thyroid-associated ophthalmopathy; DON = dysthyroid optic neuropathy; Control (C) = control subjects; Non-DON (N) = TAO patients without DON; DON (D) = TAO patients with DON; SRCL = superficial retinal capillary layer; DRCL = deep retinal capillary layer; C = central region; TAZ = total annular zone; C1~C6 = six annular zones; S = superior sector; T = temporal sector; I = inferior sector; N = nasal sector. Bold P-value represents < 0.01