| Layers | Regions | Control (C) | Non-DON (N) | DON (D) | P Value (C vs. N) | P Value (C vs. D) | P Value (N vs. D) |
|---|
| SRCL (%) | TAZ | 63.7 ± 3.3 | 60.0 ± 3.5 | 59.8 ± 4.5 | < 0.001 | < 0.001 | 0.807 |
| C1 | 57.6 ± 12.9 | 48.5 ± 14.6 | 51.1 ± 11.6 | 0.003 | 0.033 | 0.382 |
| C2 | 63.0 ± 5.6 | 60.6 ± 5.8 | 60.8 ± 5.2 | 0.069 | 0.092 | 0.869 |
| C3 | 64.0 ± 4.5 | 61.0 ± 4.3 | 61.2 ± 5.5 | 0.008 | 0.011 | 0.867 |
| C4 | 64.4 ± 3.7 | 61.4 ± 4.0 | 60.3 ± 5.3 | 0.003 | < 0.001 | 0.326 |
| C5 | 64.8 ± 3.1 | 60.8 ± 3.8 | 60.9 ± 5.0 | < 0.001 | < 0.001 | 0.899 |
| C6 | 64.2 ± 2.9 | 61.4 ± 3.6 | 60.0 ± 4.4 | 0.001 | < 0.001 | 0.127 |
| S | 63.4 ± 3.9 | 60.3 ± 4.3 | 60.0 ± 5.3 | 0.004 | 0.001 | 0.789 |
| T | 64.0 ± 3.5 | 61.2 ± 4.2 | 60.3 ± 5.0 | 0.005 | < 0.001 | 0.385 |
| I | 63.7 ± 3.6 | 59.7 ± 4.0 | 59.5 ± 5.6 | < 0.001 | < 0.001 | 0.857 |
| N | 63.6 ± 4.3 | 59.0 ± 4.0 | 59.5 ± 4.5 | < 0.001 | < 0.001 | 0.652 |
| DRCL (%) | TAZ | 73.9 ± 4.8 | 70.2 ± 4.4 | 66.4 ± 7.7 | 0.007 | < 0.001 | 0.006 |
| C1 | 40.6 ± 18.8 | 34.0 ± 16.2 | 29.7 ± 15.3 | 0.096 | 0.006 | 0.277 |
| C2 | 71.6 ± 8.5 | 66.7 ± 8.4 | 61.3 ± 12.4 | 0.039 | < 0.001 | 0.020 |
| C3 | 78.3 ± 4.1 | 75.2 ± 4.3 | 71.9 ± 7.5 | 0.016 | < 0.001 | 0.013 |
| C4 | 78.4 ± 4.0 | 75.9 ± 3.6 | 72.3 ± 7.4 | 0.045 | < 0.001 | 0.004 |
| C5 | 77.8 ± 3.6 | 74.4 ± 3.9 | 71.3 ± 7.7 | 0.007 | < 0.001 | 0.017 |
| C6 | 76.5 ± 4.2 | 72.9 ± 4.1 | 68.9 ± 8.1 | 0.009 | < 0.001 | 0.004 |
| S | 75.0 ± 4.6 | 71.2 ± 4.1 | 68.0 ± 8.1 | 0.008 | < 0.001 | 0.020 |
| T | 73.4 ± 4.7 | 69.4 ± 5.1 | 65.1 ± 9.2 | 0.011 | < 0.001 | 0.007 |
| I | 75.0 ± 4.9 | 71.5 ± 4.9 | 67.7 ± 7.0 | 0.009 | < 0.001 | 0.005 |
| N | 72.4 ± 5.7 | 68.8 ± 4.6 | 64.8 ± 7.9 | 0.017 | < 0.001 | 0.007 |
- RCD = retinal capillary density; TAO = thyroid-associated ophthalmopathy; DON = dysthyroid optic neuropathy; Control (C) = control subjects; Non-DON (N) = TAO patients without DON; DON (D) = TAO patients with DON; SRCL = superficial retinal capillary layer; DRCL = deep retinal capillary layer; C = central region; TAZ = total annular zone; C1~C6 = six annular zones; S = superior sector; T = temporal sector; I = inferior sector; N = nasal sector. Bold P-value represents < 0.01
