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Table 2 Comparisons of inner intra-retinal layer thickness among controls and TAO patients with and without DON

From: Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy

Layers

Regions

Control (C)

Non-DON (N)

DON (D)

P Value (C vs. N)

P Value (C vs. D)

P Value (N vs. D)

NFL (μm)

C

6.9 ± 1.3

6.2 ± 1.7

6.9 ± 1.3

0.032

0.927

0.039

TAZ

19.9 ± 3.2

17.7 ± 2.1

17.4 ± 1.3

< 0.001

< 0.001

0.585

S

21.4 ± 3.6

19.1 ± 3.3

18.0 ± 1.9

0.001

< 0.001

0.126

T

17.0 ± 2.7

15.5 ± 1.9

15.3 ± 1.9

0.005

0.001

0.681

I

22.2 ± 3.6

19.1 ± 3.3

18.0 ± 1.9

0.001

< 0.001

0.920

N

19.3 ± 4.6

16.3 ± 2.2

16.5 ± 1.8

< 0.001

< 0.001

0.778

GCL + IPL (μm)

C

14.6 ± 4.2

12.0 ± 4.1

12.0 ± 3.4

0.005

0.005

0.958

TAZ

75.4 ± 8.3

69.6 ± 10.2

67.1 ± 13.1

0.021

0.001

0.347

S

79.5 ± 9.6

71.6 ± 11.0

69.2 ± 14.2

0.005

< 0.001

0.387

T

72.0 ± 13.4

65.1 ± 10.4

62.7 ± 12.8

0.018

0.001

0.406

I

79.5 ± 9.6

71.6 ± 11.0

69.2 ± 14.2

0.005

< 0.001

0.337

N

74.9 ± 9.8

66.8 ± 10.6

64.9 ± 13.2

0.003

< 0.001

0.479

GCC (μm)

C

21.5 ± 5.0

18.2 ± 5.0

18.9 ± 3.7

0.002

0.015

0.499

TAZ

95.2 ± 10.3

87.3 ± 11.8

84.5 ± 13.4

0.005

< 0.001

0.341

S

100.8 ± 12.0

90.6 ± 13.1

87.2 ± 15.0

0.001

< 0.001

0.270

T

88.9 ± 14.5

80.6 ± 11.8

78.0 ± 11.9

0.006

< 0.001

0.386

I

101.6 ± 13.1

92.7 ± 12.5

90.1 ± 14.0

0.005

< 0.001

0.400

N

94.2 ± 13.2

83.1 ± 12.2

81.4 ± 13.2

< 0.001

< 0.001

0.581

INL + ORL (μm)

C

202.2 ± 41.2

202.9 ± 9.6

206.3 ± 26.4

0.921

0.549

0.623

TAZ

219.3 ± 9.4

218.4 ± 7.1

221.4 ± 9.4

0.655

0.304

0.146

S

219.6 ± 9.9

219.3 ± 7.5

221.6 ± 9.2

0.866

0.349

0.275

T

221.8 ± 10.5

220.2 ± 8.2

224.0 ± 10.2

0.468

0.343

0.098

I

216.5 ± 8.0

216.6 ± 7.2

219.9 ± 9.3

0.968

0.081

0.092

N

218.6 ± 9.6

217.1 ± 6.8

220.5 ± 10.0

0.466

0.370

0.108

Total (μm)

C

213.3 ± 51.3

214.7 ± 14.9

215.8 ± 36.9

0.870

0.771

0.901

TAZ

314.1 ± 17.5

305.4 ± 15.8

305.7 ± 12.8

0.019

0.021

0.937

S

320.2 ± 19.5

309.7 ± 17.1

308.5 ± 14.8

0.011

0.004

0.772

T

315.9 ± 21.8

302.9 ± 17.5

305.0 ± 14.9

0.003

0.012

0.635

I

318.1 ± 19.1

309.2 ± 15.4

309.6 ± 12.9

0.020

0.025

0.915

N

307.0 ± 21.5

297.1 ± 15.0

298.0 ± 11.5

0.012

0.021

0.806

  1. TAO = thyroid-associated ophthalmopathy; DON = dysthyroid optic neuropathy; Control (C) = control subjects; Non-DON (N) = TAO patients without DON; DON (D) = TAO patients with DON; NFL = nerve fiber layer; GCL + IPL = ganglion cell layer and inner plexiform layer; GCC = ganglion cell complex; INL = inner nuclear layer; ORL = outer retinal layer; C = central region; TAZ = total annular zone; S = superior sector; T = temporal sector; I = inferior sector; N = nasal sector. Bold P-value represents < 0.01
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Eye and Vision

ISSN: 2326-0254