Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy

Wu, Yufei; Tu, Yunhai; Wu, Chaoming; Bao, Lulu; Wang, Jianhua; Lu, Fan; Shen, Meixiao; Chen, Qi

doi:10.1186/s40662-020-00180-9

Eye and Vision

Table 2 Comparisons of inner intra-retinal layer thickness among controls and TAO patients with and without DON

From: Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy

Layers	Regions	Control (C)	Non-DON (N)	DON (D)	P Value (C vs. N)	P Value (C vs. D)	P Value (N vs. D)
NFL (μm)	C	6.9 ± 1.3	6.2 ± 1.7	6.9 ± 1.3	0.032	0.927	0.039
	TAZ	19.9 ± 3.2	17.7 ± 2.1	17.4 ± 1.3	< 0.001	< 0.001	0.585
	S	21.4 ± 3.6	19.1 ± 3.3	18.0 ± 1.9	0.001	< 0.001	0.126
	T	17.0 ± 2.7	15.5 ± 1.9	15.3 ± 1.9	0.005	0.001	0.681
	I	22.2 ± 3.6	19.1 ± 3.3	18.0 ± 1.9	0.001	< 0.001	0.920
	N	19.3 ± 4.6	16.3 ± 2.2	16.5 ± 1.8	< 0.001	< 0.001	0.778
GCL + IPL (μm)	C	14.6 ± 4.2	12.0 ± 4.1	12.0 ± 3.4	0.005	0.005	0.958
	TAZ	75.4 ± 8.3	69.6 ± 10.2	67.1 ± 13.1	0.021	0.001	0.347
	S	79.5 ± 9.6	71.6 ± 11.0	69.2 ± 14.2	0.005	< 0.001	0.387
	T	72.0 ± 13.4	65.1 ± 10.4	62.7 ± 12.8	0.018	0.001	0.406
	I	79.5 ± 9.6	71.6 ± 11.0	69.2 ± 14.2	0.005	< 0.001	0.337
	N	74.9 ± 9.8	66.8 ± 10.6	64.9 ± 13.2	0.003	< 0.001	0.479
GCC (μm)	C	21.5 ± 5.0	18.2 ± 5.0	18.9 ± 3.7	0.002	0.015	0.499
	TAZ	95.2 ± 10.3	87.3 ± 11.8	84.5 ± 13.4	0.005	< 0.001	0.341
	S	100.8 ± 12.0	90.6 ± 13.1	87.2 ± 15.0	0.001	< 0.001	0.270
	T	88.9 ± 14.5	80.6 ± 11.8	78.0 ± 11.9	0.006	< 0.001	0.386
	I	101.6 ± 13.1	92.7 ± 12.5	90.1 ± 14.0	0.005	< 0.001	0.400
	N	94.2 ± 13.2	83.1 ± 12.2	81.4 ± 13.2	< 0.001	< 0.001	0.581
INL + ORL (μm)	C	202.2 ± 41.2	202.9 ± 9.6	206.3 ± 26.4	0.921	0.549	0.623
	TAZ	219.3 ± 9.4	218.4 ± 7.1	221.4 ± 9.4	0.655	0.304	0.146
	S	219.6 ± 9.9	219.3 ± 7.5	221.6 ± 9.2	0.866	0.349	0.275
	T	221.8 ± 10.5	220.2 ± 8.2	224.0 ± 10.2	0.468	0.343	0.098
	I	216.5 ± 8.0	216.6 ± 7.2	219.9 ± 9.3	0.968	0.081	0.092
	N	218.6 ± 9.6	217.1 ± 6.8	220.5 ± 10.0	0.466	0.370	0.108
Total (μm)	C	213.3 ± 51.3	214.7 ± 14.9	215.8 ± 36.9	0.870	0.771	0.901
	TAZ	314.1 ± 17.5	305.4 ± 15.8	305.7 ± 12.8	0.019	0.021	0.937
	S	320.2 ± 19.5	309.7 ± 17.1	308.5 ± 14.8	0.011	0.004	0.772
	T	315.9 ± 21.8	302.9 ± 17.5	305.0 ± 14.9	0.003	0.012	0.635
	I	318.1 ± 19.1	309.2 ± 15.4	309.6 ± 12.9	0.020	0.025	0.915
	N	307.0 ± 21.5	297.1 ± 15.0	298.0 ± 11.5	0.012	0.021	0.806

TAO = thyroid-associated ophthalmopathy; DON = dysthyroid optic neuropathy; Control (C) = control subjects; Non-DON (N) = TAO patients without DON; DON (D) = TAO patients with DON; NFL = nerve fiber layer; GCL + IPL = ganglion cell layer and inner plexiform layer; GCC = ganglion cell complex; INL = inner nuclear layer; ORL = outer retinal layer; C = central region; TAZ = total annular zone; S = superior sector; T = temporal sector; I = inferior sector; N = nasal sector. Bold P-value represents < 0.01

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