Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes

Tang, Fang Yao; Chan, Erica O.; Sun, Zihan; Wong, Raymond; Lok, Jerry; Szeto, Simon; Chan, Jason C.; Lam, Alexander; Tham, Clement C.; Ng, Danny S.; Cheung, Carol Y.

doi:10.1186/s40662-019-0173-y

Eye and Vision

Table 3 Multiple regression models of (a) foveal avascular zone area, (b) vessel density, (c) fractal dimension with variables that showed significant associations in univariate analysis, excluding eyes without DME

From: Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes

	Beta coefficient	Standard error	95% CI	P-value
(a) Foveal Avascular Zone (FAZ) Area
Severity of DR
Severe NPDR or PDR vs. No DR	0.381	0.379	− 0.363 to 1.124	0.316
Moderate NPDR vs. No DR	0.157	0.157	− 0.152 to 0.465	0.319
Mild NPDR vs. No DR	0.256	0.143	−0.024 to 0.535	0.073
LogMAR, per SD increase	0.109	0.063	−0.014 to 0.233	0.083
Axial length, per SD increase	−0.201	0.057	−0.313 to − 0.089	< 0.001
Subfoveal choroidal thickness, per SD increase	−0.131	0.062	−0.252 to − 0.010	0.035
Body mass index, per SD increase	−0.083	0.049	−0.139 to 0.014	0.094
Systolic blood pressure, per SD increase	0.065	0.068	−0.067 to 0.198	0.335
Age, per SD increase	0.064	0.056	−0.046 to 0.174	0.253
>(b) Vessel Density (VD)
Severity of DR
Severe NPDR or PDR vs. No DR	−0.618	0.275	−1.158 to − 0.079	0.025
Moderate NPDR vs. No DR	−0.313	0.154	−0.614 to − 0.012	0.042
Mild NPDR vs. No DR	−0.325	0.133	−0.586 to − 0.064	0.015
Axial length, per SD increase	0.0130	0.056	0.021 to 0.239	0.019
LogMAR, per SD increase	−0.125	0.056	−0.235 to − 0.014	0.027
Subfoveal choroidal thickness, per SD increase	0.125	0.059	0.010 to 0.240	0.034
Body mass index, per SD increase	0.081	0.060	−0.037 to 0.199	0.177
Systolic blood pressure, per SD increase	−0.040	0.061	−0.159 to 0.078	0.504
Age, per SD increase	−0.095	0.062	−0.216 to 0.026	0.123
(c) Fractal Dimension (FD)
Severity of DR
Severe NPDR or PDR vs. No DR	−0.810	0.201	−1.204 to − 0.417	< 0.001
Moderate NPDR vs. No DR	−0.339	0.191	−0.714 to 0.036	0.076
Mild NPDR vs. No DR	−0.310	0.126	−0.556 to − 0.064	0.014
LogMAR, per SD increase	−0.023	0.095	−0.208 to 0.162	0.808
Average GC-IPL, per SD increase	−0.006	0.045	−0.095 to 0.082	0.893
Body mass index, per SD increase	0.099	0.045	0.011 to 0.187	0.028
Systolic blood pressure, per SD increase	0.033	0.054	−0.073 to 0.140	0.540
Age, per SD increase	−0.166	0.055	−0.275 to − 0.058	0.003

DME= diabetic macular edema; CI= confidence interval; SD= standard deviation; DR= diabetic retinopathy; NPDR= non-proliferative diabetic retinopathy; PDR= proliferative diabetic retinopathy; GC-IPL= ganglion cell inner plexiform layer; LogMAR= logarithm of the minimum angle of resolution

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