Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes

Tang, Fang Yao; Chan, Erica O.; Sun, Zihan; Wong, Raymond; Lok, Jerry; Szeto, Simon; Chan, Jason C.; Lam, Alexander; Tham, Clement C.; Ng, Danny S.; Cheung, Carol Y.

doi:10.1186/s40662-019-0173-y

Eye and Vision

Table 2 Multiple regression models of (a) foveal avascular zone area, (b) vessel density, (c) fractal dimension with variables that showed significant associations in univariate analysis

From: Clinically relevant factors associated with quantitative optical coherence tomography angiography metrics in deep capillary plexus in patients with diabetes

	Beta coefficient	Standard error	95% CI	P-value
(a) Foveal Avascular Zone (FAZ) Area
Severity of DR
Severe NPDR or PDR vs. No DR	0.687	0.330	0.041 to 1.333	0.037
Moderate NPDR vs. No DR	0.103	0.148	−0.187 to 0.392	0.487
Mild NPDR vs. No DR	0.221	0.130	−0.034 to 0.475	0.089
Presence of DME	0.138	0.171	− 0.196 to 0.473	0.418
LogMAR, per SD increase	0.102	0.058	−0.012 to 0.215	0.079
Axial length, per SD increase	−0.171	0.057	−0.282 to − 0.059	0.003
Subfoveal choroidal thickness, per SD increase	−0.122	0.056	−0.232 to − 0.011	0.031
Body mass index, per SD increase	−0.090	0.046	−0.180 to − 0.001	0.047
Systolic blood pressure, per SD increase	0.077	0.067	−0.053 to 0.207	0.246
Age, per SD increase	0.051	0.053	−0.052 to 0.154	0.336
(b) Vessel Density (VD)
Severity of DR
Severe NPDR or PDR vs. No DR	−0.842	0.245	−1.322 to − 0.363	0.001
Moderate NPDR vs. No DR	−0.249	0.145	−0.532 to 0.035	0.085
Mild NPDR vs. No DR	−0.345	0.124	−0.588 to − 0.101	0.006
Presence of DME	−0.160	0.167	−0.488 to 0.168	0.340
Axial length, per SD increase	0.107	0.052	0.005 to 0.209	0.039
LogMAR, per SD increase	−0.133	0.057	−0.245 to − 0.020	0.021
Subfoveal choroidal thickness, per SD increase	0.104	0.056	−0.005 to 0.213	0.062
Body mass index, per SD increase	0.073	0.054	−0.033 to 0.178	0.176
Systolic blood pressure, per SD increase	−0.030	0.057	−0.143 to 0.082	0.595
Age, per SD increase	−0.078	0.058	−0.192 to 0.036	0.182
(c) Fractal Dimension (FD)
Severity of DR
Severe NPDR or PDR vs. No DR	−0.891	0.225	−1.331 to − 0.451	< 0.001
Moderate NPDR vs. No DR	−0.357	0.128	−0.607 to − 0.107	0.005
Mild NPDR vs. No DR	−0.307	0.109	−0.521 to − 0.093	0.005
LogMAR, per SD increase	−0.074	0.055	−0.183 to 0.034	0.180
Average GC-IPL, per SD increase	0.113	0.054	0.007 to 0.220	0.037
Body mass index, per SD increase	0.077	0.037	0.005 to 0.149	0.035
Systolic blood pressure, per SD increase	0.062	0.045	−0.026 to 0.151	0.168
Age, per SD increase	−0.142	0.050	−0.239 to − 0.044	0.004

CI= confidence interval; SD= standard deviation; DR= diabetic retinopathy; NPDR= non-proliferative diabetic retinopathy; PDR= proliferative diabetic retinopathy; DME= diabetic macular edema; GC-IPL= ganglion cell inner plexiform layer; LogMAR= logarithm of the minimum angle of resolution

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