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Table 4 Logistic regression analysis for the assessment of AMD associated genes with KC in males

From: Do age-related macular degeneration genes show association with keratoconus?

  Without age adjustment Adjusting for age
CHR SNP Minor Allele Name Odds Ratio (95% CI) P Odds Ratio (95% CI) P
22 rs5749482 C 2.29 (1.41–3.71) 7.7 × 10−4 1.76 (1.01–3.08) 4.8 × 10−2
3 rs6795735 T 1.60 (1.15–2.23) 5.4 × 10− 3 1.36 (0.93–1.99) 1.1 × 10− 1
6 rs943080 C 0.68 (0.50–0.94) 1.9 × 10−2 0.75 (0.52–1.09) 1.4 × 10− 1
13 rs9542236 C 0.72 (0.52–1.00) 4.8 × 10−2 0.97 (0.66–1.42) 8.7 × 10− 1
10 rs10490924 T 1.44 (0.99–2.10) 5.7 × 10−2 1.54 (0.99–2.40) 5.4 × 10− 2
6 rs429608 A 1.49 (0.95–2.34) 7.9 × 10−2 1.77 (1.05–2.99) 3.1 × 10− 2
15 rs920915 C 0.75 (0.54–1.05) 8.9 × 10−2 0.82 (0.56–1.21) 3.2 × 10−1
14 rs8017304 G 1.31 (0.93–1.85) 1.2 × 10−1 1.31 (0.88–1.96) 1.9 × 10−1
9 rs334353 G 0.85 (0.59–1.23) 4.0 × 10−1 0.91 (0.59–1.39) 6.6 × 10− 1
8 rs13278062 G 0.88 (0.64–1.23) 4.6 × 10−1 0.85 (0.58–1.25) 4.1 × 10−1
16 rs1864163 A 0.86 (0.57–1.29) 4.6 × 10−1 0.92 (0.58–1.47) 7.4 × 10− 1
6 rs3812111 A 0.89 (0.64–1.24) 4.9 × 10−1 0.81 (0.55–1.19) 2.8 × 10−1
19 rs2230199 G 0.88 (0.58–1.33) 5.4 × 10−1 1.05 (0.65–1.71) 8.3 × 10− 1
22 rs8135665 A 1.09 (0.73–1.63) 6.6 × 10−1 1.35 (0.85–2.17) 2.1 × 10−1
4 rs4698775 G 0.96 (0.67–1.37) 8.2 × 10−1 1.05 (0.69–1.60) 8.3 × 10− 1
19 rs4420638 G 1.05 (0.70–1.57) 8.3 × 10−1 0.90 (0.56–1.46) 6.8 × 10−1
6 rs3130783 G 0.98 (0.66–1.45) 9.1 × 10−1 1.10 (0.69–1.75) 7.0 × 10− 1
1 rs10737680 C 1.01 (0.72–1.42) 9.6 × 10−1 0.78 (0.52–1.17) 2.2 × 10−1
  1. AMD = age-related macular degeneration, KC = keratoconus, CHR = chromosome, CI = confidence intervals, SNP = single nucleotide polymorphisms
  2. P value for statistical significance is 0.05/18  = 2.8 × 10−3
  3. Bolded value indicates significance
  4. 95% CI – 95% confidence interval