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Table 4 Logistic regression analysis for the assessment of AMD associated genes with KC in males

From: Do age-related macular degeneration genes show association with keratoconus?

 Without age adjustmentAdjusting for age
CHRSNPMinor Allele NameOdds Ratio (95% CI)POdds Ratio (95% CI)P
22rs5749482C2.29 (1.41–3.71)7.7 × 10−41.76 (1.01–3.08)4.8 × 10−2
3rs6795735T1.60 (1.15–2.23)5.4 × 10− 31.36 (0.93–1.99)1.1 × 10− 1
6rs943080C0.68 (0.50–0.94)1.9 × 10−20.75 (0.52–1.09)1.4 × 10− 1
13rs9542236C0.72 (0.52–1.00)4.8 × 10−20.97 (0.66–1.42)8.7 × 10− 1
10rs10490924T1.44 (0.99–2.10)5.7 × 10−21.54 (0.99–2.40)5.4 × 10− 2
6rs429608A1.49 (0.95–2.34)7.9 × 10−21.77 (1.05–2.99)3.1 × 10− 2
15rs920915C0.75 (0.54–1.05)8.9 × 10−20.82 (0.56–1.21)3.2 × 10−1
14rs8017304G1.31 (0.93–1.85)1.2 × 10−11.31 (0.88–1.96)1.9 × 10−1
9rs334353G0.85 (0.59–1.23)4.0 × 10−10.91 (0.59–1.39)6.6 × 10− 1
8rs13278062G0.88 (0.64–1.23)4.6 × 10−10.85 (0.58–1.25)4.1 × 10−1
16rs1864163A0.86 (0.57–1.29)4.6 × 10−10.92 (0.58–1.47)7.4 × 10− 1
6rs3812111A0.89 (0.64–1.24)4.9 × 10−10.81 (0.55–1.19)2.8 × 10−1
19rs2230199G0.88 (0.58–1.33)5.4 × 10−11.05 (0.65–1.71)8.3 × 10− 1
22rs8135665A1.09 (0.73–1.63)6.6 × 10−11.35 (0.85–2.17)2.1 × 10−1
4rs4698775G0.96 (0.67–1.37)8.2 × 10−11.05 (0.69–1.60)8.3 × 10− 1
19rs4420638G1.05 (0.70–1.57)8.3 × 10−10.90 (0.56–1.46)6.8 × 10−1
6rs3130783G0.98 (0.66–1.45)9.1 × 10−11.10 (0.69–1.75)7.0 × 10− 1
1rs10737680C1.01 (0.72–1.42)9.6 × 10−10.78 (0.52–1.17)2.2 × 10−1
  1. AMD = age-related macular degeneration, KC = keratoconus, CHR = chromosome, CI = confidence intervals, SNP = single nucleotide polymorphisms
  2. P value for statistical significance is 0.05/18  = 2.8 × 10−3
  3. Bolded value indicates significance
  4. 95% CI – 95% confidence interval