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Table 3 Logistic regression analysis for the assessment of AMD associated genes with KC in both genders

From: Do age-related macular degeneration genes show association with keratoconus?

  Without adjusting for age & gender Adjusting for age & gender
CHR SNP Minor Allele Name Odds Ratio (95% CI) P Odds Ratio (95% CI) P
3 rs6795735 T 1.52 (1.21–1.92) 3.5 × 10−4 1.35 (1.04–1.75) 2.2 × 10−2
22 rs5749482 C 1.53 (1.13–2.09) 6.6 × 10− 3 1.28 (0.90–1.82) 1.7 × 10− 1
13 rs9542236 C 0.73 (0.58–0.92) 7.8 × 10− 3 0.82 (0.64–1.07) 1.4 × 10− 1
10 rs10490924 T 1.34 (1.03–1.76) 3.1 × 10−2 1.27 (0.94–1.72) 1.2 × 10− 1
6 rs943080 C 0.79 (0.63–0.99) 4.0 × 10−2 0.91 (0.70–1.17) 4.4 × 10− 1
19 rs2230199 G 0.79 (0.58–1.07) 1.2 × 10− 1 0.77 (0.55–1.09) 1.4 × 10− 1
6 rs429608 A 1.25 (0.92–1.70) 1.5 × 10− 1 1.33 (0.94–1.88) 1.1 × 10− 1
16 rs1864163 A 0.82 (0.63–1.08) 1.5 × 10−1 0.95 (0.70–1.28) 7.1 × 10− 1
4 rs4698775 G 1.20 (0.93–1.55) 1.6 × 10−1 1.27 (0.95–1.69) 1.0 × 10− 1
15 rs920915 C 0.85 (0.68–1.07) 1.7 × 10−1 0.89 (0.69–1.16) 3.8 × 10− 1
1 rs10737680 C 1.14 (0.91–1.43) 2.6 × 10−1 1.02 (0.79–1.32) 8.7 × 10− 1
6 rs3812111 A 0.88 (0.70–1.11) 2.7 × 10−1 0.82 (0.63–1.06) 1.3 × 10− 1
8 rs13278062 G 0.90 (0.72–1.13) 3.7 × 10−1 0.89 (0.70–1.15) 3.8 × 10− 1
14 rs8017304 G 1.11 (0.88–1.39) 3.9 × 10−1 1.06 (0.82–1.37) 6.5 × 10− 1
6 rs3130783 G 0.90 (0.68–1.19) 4.7 × 10−1 0.93 (0.68–1.26) 6.3 × 10− 1
19 rs4420638 G 0.91 (0.68–1.21) 5.1 × 10−1 0.83 (0.60–1.16) 2.7 × 10− 1
22 rs8135665 A 1.08 (0.81–1.45) 6.0 × 10−1 1.28 (0.92–1.79) 1.4 × 10− 1
9 rs334353 G 0.97 (0.75–1.25) 8.0 × 10−1 1.00 (0.75–1.34) 9.8 × 10− 1
  1. AMD = age-related macular degeneration, KC = keratoconus, CI = confidence intervals, CHR = chromosome, SNP = single nucleotide polymorphisms
  2. P value for statistical significance is 0.05/18  =  2.8 × 10−3
  3. Bolded value indicates significance
  4. 95% CI – 95% confidence interval