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Table 3 Logistic regression analysis for the assessment of AMD associated genes with KC in both genders

From: Do age-related macular degeneration genes show association with keratoconus?

 Without adjusting for age & genderAdjusting for age & gender
CHRSNPMinor Allele NameOdds Ratio (95% CI)POdds Ratio (95% CI)P
3rs6795735T1.52 (1.21–1.92)3.5 × 10−41.35 (1.04–1.75)2.2 × 10−2
22rs5749482C1.53 (1.13–2.09)6.6 × 10− 31.28 (0.90–1.82)1.7 × 10− 1
13rs9542236C0.73 (0.58–0.92)7.8 × 10− 30.82 (0.64–1.07)1.4 × 10− 1
10rs10490924T1.34 (1.03–1.76)3.1 × 10−21.27 (0.94–1.72)1.2 × 10− 1
6rs943080C0.79 (0.63–0.99)4.0 × 10−20.91 (0.70–1.17)4.4 × 10− 1
19rs2230199G0.79 (0.58–1.07)1.2 × 10− 10.77 (0.55–1.09)1.4 × 10− 1
6rs429608A1.25 (0.92–1.70)1.5 × 10− 11.33 (0.94–1.88)1.1 × 10− 1
16rs1864163A0.82 (0.63–1.08)1.5 × 10−10.95 (0.70–1.28)7.1 × 10− 1
4rs4698775G1.20 (0.93–1.55)1.6 × 10−11.27 (0.95–1.69)1.0 × 10− 1
15rs920915C0.85 (0.68–1.07)1.7 × 10−10.89 (0.69–1.16)3.8 × 10− 1
1rs10737680C1.14 (0.91–1.43)2.6 × 10−11.02 (0.79–1.32)8.7 × 10− 1
6rs3812111A0.88 (0.70–1.11)2.7 × 10−10.82 (0.63–1.06)1.3 × 10− 1
8rs13278062G0.90 (0.72–1.13)3.7 × 10−10.89 (0.70–1.15)3.8 × 10− 1
14rs8017304G1.11 (0.88–1.39)3.9 × 10−11.06 (0.82–1.37)6.5 × 10− 1
6rs3130783G0.90 (0.68–1.19)4.7 × 10−10.93 (0.68–1.26)6.3 × 10− 1
19rs4420638G0.91 (0.68–1.21)5.1 × 10−10.83 (0.60–1.16)2.7 × 10− 1
22rs8135665A1.08 (0.81–1.45)6.0 × 10−11.28 (0.92–1.79)1.4 × 10− 1
9rs334353G0.97 (0.75–1.25)8.0 × 10−11.00 (0.75–1.34)9.8 × 10− 1
  1. AMD = age-related macular degeneration, KC = keratoconus, CI = confidence intervals, CHR = chromosome, SNP = single nucleotide polymorphisms
  2. P value for statistical significance is 0.05/18  =  2.8 × 10−3
  3. Bolded value indicates significance
  4. 95% CI – 95% confidence interval