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Table 2 Allelic association of SNPs in C5 with neovascular AMD and PCV

From: Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy

SNP

Location

Codon change

Minor allele

Minor allele frequency

Allelic association

AMD

PCV

Control

AMD-control

PCV-control

AMD-PCV

(n = 400)

(n = 466)

(n = 550)

P

OR (95% CI)

P

OR (95% CI)

P

OR (95% CI)

rs1017119

intron 2

–

C

0.16

0.15

0.14

0.54

1.12 (0.78–1.61)

0.70

1.07 (0.76–1.52)

0.82

0.96 (0.66–1.39)

rs10985126

exon 11

G385G

C

0.24

0.23

0.24

0.83

0.97 (0.72–1.31)

0.66

0.94 (0.70–1.25)

0.84

0.97 (0.71–1.33)

rs1548782

intron 18

–

T

0.21

0.24

0.20

0.83

1.04 (0.75–1.42)

0.15

1.25 (0.93–1.68)

0.26

1.20 (0.87–1.66)

rs17611

exon 19

V802I

G

0.41

0.42

0.41

0.85

0.98 (0.75–1.27)

0.67

1.06 (0.82–1.36)

0.57

1.08 (0.82–1.42)

rs2269066

intron 30

–

T

0.20

0.19

0.22

0.44

0.88 (0.64–1.21)

0.28

0.84 (0.62–1.15)

0.79

0.96 (0.68–1.34)

rs12237774

exon 34

A1422A

T

0.18

0.17

0.20

0.54

0.90 (0.65–1.26)

0.18

0.80 (0.58–1.11)

0.50

0.89 (0.62–1.26)

  1. AMD= age-related macular degeneration, CI= confidence interval, OR= odds ratio, PCV= polypoidal choroidal vasculopathy, SNP= single nucleotide polymorphism