Evaluation of FGF10 as a candidate gene for high myopia in a Han Chinese population

Table 5 Association analysis between rs10462070 and HM/EM in 4 genetic models

Group	Genotype (n)			Genetic Model	OR (95% CI)	P ^*	Corrected P^**
Group	GG	GA	AA	Genetic Model	OR (95% CI)	P ^*	Corrected P^**
Control	15 (0.017)	178 (0.198)	706 (0.785)
HM	5 (0.006)	183 (0.211)	681 (0.784)	Homozygote	0.346 (0.123–0.956)	0.032	0.128
				Heterozygote	1.067 (0.845–1.344)	0.590	1
				Dominant	1.001 (0.805–1.267)	0.932	1
				Recessive	0.341 (0.123–0.942)	0.030	0.128
EM	1 (0.002)	109 (0.225)	375 (0.773)	Homozygote	0.126 (0.017–0.954)	0.017	0.068
				Heterozygote	1.153 (0.881–1.509)	0.300	1
				Dominant	1.073 (0.823–1.400)	0.603	1
				Recessive	0.122 (0.016–0.925)	0.015	0.060

Genotype analyses were conducted for the homozygote model (GG compared with AA), heterozygote model (GA compared with AA), dominant model (GG + GA compared with AA), and the recessive model (GG compared with GA + AA)
HM = high myopia, EM = extreme myopia, OR = odds ratio, CI = confidence interval
^* P value has been adjusted for age and sex
^** Corrected P = P × 4 (the number of genetic models)

ISSN: 2326-0254