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Table 4 Enriched Gene Ontology terms and KEGG pathway identified for proteins with reduced expression in C-AME (< 0.5-fold) compared to F-AME

From: A cellular and proteomic approach to assess proteins extracted from cryopreserved human amnion in the cultivation of corneal stromal keratocytes for stromal cell therapy

 

Enrichment scores

Biological pathways

Proteins (UniProt Accession no.)

p

(A) Enriched GO terms (DAVID)

 1

15.19

GO:0098609~cell-cell adhesion

P07355, P62820, Q8WUF5, P61026, P31947, P06733, P04075, Q9H444, P43487, Q9C0C2, P30041, Q15056, P46109, P31949, Q15907, Q99497, Q9UJU6, O60437, P00338, Q92817, P31939, Q16643, P20810, Q9NYL9, P0DMV9, Q16658, P63244, Q14847, Q8NC51, Q14247

1.3E-12*

 2

6.45

GO:0043488~regulation of mRNA stability

P27695, P25788, P25789, P25786, P0DMV9, P20618, P28070, O14818, Q92945, P60900, P49721, P04792, P49720, Q8NC51, P28066

2E-6*

 3

6.45

GO:0051603~proteolysis involved in cellular protein catabolic process

P20618, P25788, P25789, P25786, P28070, O14818, P07858, P60900, P49721, P49720

1E-4*

 3

4.23

GO:0006096~glycolytic process

P60174, P04406, P00558, P04075, P00338, P06733, P06744

0.026*

(B) KEGG pathways (DAVID)

 1

6.45

hsa03050:Proteasome

P20618, P25788, P25789, P25786, P28070, O14818, P60900, P49721, P49720, P28066

3.6E-4*

 2

4.23

hsa01130:Biosynthesis of antibiotics

P40925, P60174, P04406, P37837, P06733, P00338, P04075, Q03154, P06744, P31939, P11766, P54687, P29401, P14324, P00558, P14550, P21399

0.014*

  1. GO = gene ontology, KEGG = kyoto encyclopedia of genes and genomes, F-AME = fresh human amnion extract, C-AME = cryopreserved human amnion extract, DAVID = database for annotation, visualization and integrated discovery
  2. The biological events were ranked using enrichment scores. *Adjusted Benjamini p < 0.05 represents statistical significance