Table 1 Demographics and clinical information of patients with clinical and sub-clinical ocular surface squamous neoplasia treated with 5-flourouracil or interferon alfa 2b eye drops
Characteristics | OSSN without Sub-clinical Disease (n = 90) | OSSN with Sub-clinical Diseasem (n = 16) | P Value |
|---|---|---|---|
Patient Information | |||
Age (years), mean (SD) | 68 (13) | 70.4 (13) | 0.45 |
Gender, male sex, % (n) | 48 (49) | 75 (12) | 0.42 |
Race, % (n) | 0.77 | ||
Black | 5 (4) | 6 (1) | |
White | 58 (49) | 75 (12) | |
Hispanic ethnicity, % (n) | 23 (20) | 56 (9) | 0.85 |
Current smoker, % (n) | 9 (8) | 0 (0) | 0.03 |
Sun exposure, % (n)a | 58 (29) | 100 (11) | 0.06 |
History of pterygium, % (n) | 21 (19) | 73 (11) | 0.67 |
History of OSSN, % (n) | 10 (9) | 0 (0) | 0.36 |
History of skin cancer, % (n) | 20 (15) | 54 (7) | 0.03 |
History of HIV, % (n) | 1 (1) | 0 (0) | 0.65 |
History of HPV, % (n) | 11 (7) | 10 (1) | 0.81 |
Clinical Information | |||
Involve eye, right % (n) | 42 (38) | 62 (10) | 0.53 |
Area (mm2), mean (SD) | 38 (34) | 34 (25) | 0.65 |
Treated with 5-FU, % (n) | 54 (43) | 44 (7) | 0.43 |
Treated with IFN, % (n) | 45 (36) | 56 (9) | |
Treated with both IFN or 5-FU, % (n) | 14 (13) | 12 (2) | 0.47 |
Location % (n)b | |||
Nasal | 45 (41) | 56 (9) | 0.75 |
Temporal | 43 (39) | 56 (9) | 0.62 |
Superior | 11 (10) | 19 (2) | 0.52 |
Inferior | 26 (23) | 37 (6) | 0.51 |
Corneal involvement, % (n) | 67 (60) | 81 (13) | 0.65 |
Corneal & conjunctival involvement, % (n) | 50 (45) | 56 (9) | 0.94 |
Clinical AJCC stage, % (n) | 0.10 | ||
T1a | 14 (13) | 25 (4) | |
T2a | 18 (16) | 13 (2) | |
T2b | 5 (4) | 6 (1) | |
T3a | 51 (45) | 56 (9) | |
Multifocal tumor, % (n) | 14 (13) | 12 (2) | 0.69 |
Appearance, % (n)c | |||
Leukoplakia | 25 (22) | 37 (6) | 0.46 |
Papillomatous | 18 (16) | 19 (3) | 0.87 |
Flat/Opalescent | 35 (31) | 44 (7) | 0.77 |
Gelatinous | 37 (33) | 44 (7) | 0.91 |